Name: Py-MPB-amino-C3-PBD
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

IUPAC Name

4-[4-[[4-[4-[[(6aS)-2-methoxy-12-oxo-6,6a,7,8,9,10-hexahydro-5H-pyrido[2,1-c][1,4]benzodiazepin-3-yl]oxy]butanoylamino]-1-methylpyrrole-2-carbonyl]amino]phenyl]-1-methyl-N-pyridin-4-ylpyrrole-2-carboxamide

Canonical SMILES

CN1C=C(C=C1C(=O)NC2=CC=NC=C2)C3=CC=C(C=C3)NC(=O)C4=CC(=CN4C)NC(=O)CCCOC5=C(C=C6C(=C5)NCC7CCCCN7C6=O)OC

InChI

InChI=1S/C41H44N8O6/c1-47-24-27(19-34(47)39(51)46-29-13-15-42-16-14-29)26-9-11-28(12-10-26)45-40(52)35-20-30(25-48(35)2)44-38(50)8-6-18-55-37-22-33-32(21-36(37)54-3)41(53)49-17-5-4-7-31(49)23-43-33/h9-16,19-22,24-25,31,43H,4-8,17-18,23H2,1-3H3,(H,44,50)(H,45,52)(H,42,46,51)/t31-/m0/s1

Solubility

10 mm in DMSO

Appearance

Solid

Shelf Life

-20°C 3 years powder; -80°C 2 years in solvent

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Form

Solid

In Vitro

Py-MPB-amino-C3-PBD (compound 73) shows cytotoxicity with IC50s of 301, 144.1 and 37.5 nM for U138-MG, A431, and REH cells, respectively. Py-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12, with potency of 2 pg/mL determined.

Py-MPB-amino-C3-PBD is a highly potent pyrrolobenzodiazepine (PBD) dimer derivative and a prominent ADC cytotoxin used as an ADC payload in antibody-drug conjugates. This compound exerts cytotoxic activity by covalently binding to the minor groove of DNA, forming interstrand cross-links that disrupt replication and transcription, ultimately inducing apoptosis in rapidly dividing tumor cells. Its exceptional potency and DNA-targeting mechanism make it a powerful tool for targeted cancer therapy applications.

Within antibody-drug conjugates, Py-MPB-amino-C3-PBD is typically conjugated to monoclonal antibodies via cleavable linkers that allow controlled intracellular release. The ADC remains stable in systemic circulation to minimize off-target toxicity, while enzymatic cleavage inside tumor cells releases the active payload. This targeted delivery ensures high tumor specificity, potent antitumor effects at low drug-to-antibody ratios (DARs), and improved therapeutic index, which are critical factors in precision oncology development.

Applications of Py-MPB-amino-C3-PBD include its use in experimental ADCs targeting both hematologic malignancies and solid tumors, such as lymphoma, leukemia, breast cancer, and ovarian cancer. Its chemical structure allows compatibility with various linker chemistries, optimizing conjugation efficiency, intracellular release, and stability. Researchers leverage Py-MPB-amino-C3-PBD to design next-generation ADCs with enhanced tumor selectivity, superior antitumor efficacy, and reduced systemic toxicity, supporting innovative approaches in targeted cancer therapeutics.

Catalog	Product Name	CAS
BADC-00340	PBD dimer	1222490-34-7
BADC-00015	MC-Val-Ala-PBD	1342820-51-2
BADC-00738	MA-PEG4-VA-PBD	1342820-68-1
BADC-01669	VA-PAB-PBD	1595275-60-7
BADC-00670	Mal-PEG4-VA-PBD	2259318-50-6
BADC-00826	Aniline-MPB-amino-C3-PBD	2412923-79-4
BADC-01377	Pyrrolobenzodiazepine (PBD)	945490-09-5
BADC-00755	DBCO-PEG4-VA-PBD

What is Py-MPB-amino-C3-PBD?

Py-MPB-amino-C3-PBD is a potent cytotoxic agent commonly used as a payload in antibody-drug conjugates. Its chemical structure allows for selective DNA minor-groove binding, leading to inhibition of DNA replication in target cells, and it is frequently employed in research focused on targeted cancer therapies.

1/2/2017

Dear BOC Sciences, how does Py-MPB-amino-C3-PBD function in ADCs?

In ADC applications, Py-MPB-amino-C3-PBD acts as a DNA-crosslinking agent. Upon internalization of the ADC into cancer cells, it induces DNA damage and triggers apoptosis. Its high cytotoxicity allows for effective killing of tumor cells at low concentrations, enhancing therapeutic efficacy.

29/10/2019

Good morning! What are the key applications of Py-MPB-amino-C3-PBD in research?

Py-MPB-amino-C3-PBD is primarily used in the development of experimental ADCs for oncology research. It enables the study of drug delivery mechanisms, cytotoxic payload optimization, and the evaluation of linker stability, contributing to preclinical ADC development strategies.

23/9/2020

Good afternoon! Could you kindly share what the chemical characteristics of Py-MPB-amino-C3-PBD are?

Py-MPB-amino-C3-PBD is characterized by a pyrrolobenzodiazepine (PBD) core linked to an amino functional group via a three-carbon spacer. This configuration facilitates DNA minor groove interaction and allows conjugation to antibodies through suitable linkers for targeted delivery.

4/3/2019

Dear team, how should Py-MPB-amino-C3-PBD be handled safely in laboratory settings?

Handling of Py-MPB-amino-C3-PBD requires strict adherence to safety protocols due to its cytotoxicity. Appropriate PPE, containment procedures, and waste disposal measures must be followed to prevent exposure and ensure laboratory safety during ADC research and conjugation experiments.

17/4/2020

— Dr. Jason Carter, Senior Scientist (USA)

Py-MPB-amino-C3-PBD delivered with high purity and stability, supporting ADC conjugation efficiently.

23/9/2020

— Dr. Michael Harris, ADC Scientist (USA)

Py-MPB-amino-C3-PBD from BOC Sciences proved highly reliable for conjugation workflows. The compound’s structural integrity was maintained even after multiple handling steps.

17/4/2020

— Ms. Clara Jensen, Biopharmaceutical Researcher (Denmark)

We required Py-MPB-amino-C3-PBD for linker-payload testing, and BOC Sciences delivered with excellent turnaround time. The material purity was exceptional.

4/3/2019

— Mr. Robert King, CMC Specialist (UK)

The detailed analytical data package accompanying Py-MPB-amino-C3-PBD made regulatory review efficient. This transparency saved our team valuable time.

1/2/2017

— Dr. Elena Fischer, Medicinal Chemist (Germany)

We observed consistent conjugation efficiency when using Py-MPB-amino-C3-PBD from BOC Sciences, making it a dependable choice for early-stage ADC programs.

— Prof. David Cooper, Chemical Biology Professor (Ireland)

From inquiry to delivery, the Py-MPB-amino-C3-PBD experience was seamless. Customer support was responsive and knowledgeable throughout.

29/10/2019