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CAS No.:
Cat No.: BADC-01262
Purity: >98%
4.5 
Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu (HY-44234).
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Popular Publications Citing BOC Sciences Products
Fmoc-Gly-Gly-D-Phe-OtBu, a versatile chemical compound, finds extensive applications in peptide synthesis and biochemical research. Here are four key applications of Fmoc-Gly-Gly-D-Phe-OtBu:
Peptide Synthesis: Serving as a fundamental component in solid-phase peptide synthesis, Fmoc-Gly-Gly-D-Phe-OtBu acts as a pivotal building block. Its Fmoc-protected N-terminal facilitates seamless peptide chain assembly, minimizing side reactions. This inherent property is indispensable for designing specific peptide sequences tailored for diverse research or therapeutic objectives.
Protein Engineering: Within the domain of protein engineering, this compound assumes a critical role in manipulating and investigating protein characteristics. By integrating specific amino acids like D-Phe, researchers can modulate protein folding, stability, and functionality. This strategic approach yields engineered proteins with desirable attributes, poised for applications in industrial or medical realms.
Pharmaceutical Development: In the realm of pharmaceutical research, Fmoc-Gly-Gly-D-Phe-OtBu holds notable significance, especially in the arena of drug design and development. Synthesized peptides utilizing this compound undergo rigorous testing for potential therapeutic actions such as enzyme inhibition or receptor binding. This process aids in identifying novel drug candidates and optimizing peptide-based therapeutics, fostering advancements in pharmaceutical science.
Chemical Biology: Within the interdisciplinary field of chemical biology, Fmoc-Gly-Gly-D-Phe-OtBu emerges as a pivotal tool for investigating biomolecular interactions. Researchers leverage this compound to synthesize peptides that interact with proteins, nucleic acids, or other biomolecules, enabling detailed exploration of biological mechanisms.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01586 | Fmoc-Gly-Gly-Gly-Gly-OH | 1001202-16-9 | |
| BADC-00972 | Fmoc-Gly-Gly-Phe-OH | 160036-44-2 | |
| BADC-01104 | Fmoc-Gly-Gly-Phe-OtBu | 236426-37-2 | |
| BADC-01815 | Fmoc-Gly-Gly-allyl propionate | 2766214-15-5 | |
| BADC-01119 | Fmoc-Gly-Gly-OH | 35665-38-4 | |
| BADC-01880 | Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz | ||
| BADC-01261 | Fmoc-Gly-Gly-D-Phe-OH |
What role does Fmoc-Gly-Gly-D-Phe-OtBu play in ADC linkers?
Fmoc-Gly-Gly-D-Phe-OtBu serves as a peptide-based linker scaffold in ADCs, allowing selective assembly of cytotoxic payloads while preserving antibody conformation and biological activity.
13/5/2019
We would like to know how Fmoc-Gly-Gly-D-Phe-OtBu is cleaved within target cells.
The peptide sequence is designed for enzymatic recognition, enabling cleavage by intracellular proteases to release the payload selectively within lysosomal compartments of target cells.
17/12/2022
Dear team, which payloads are commonly used with Fmoc-Gly-Gly-D-Phe-OtBu?
It is compatible with a range of small molecule drugs that can react with the terminal functional group, including cytotoxic agents used in clinical ADC formulations.
12/8/2017
Good morning! What design considerations are important for Fmoc-Gly-Gly-D-Phe-OtBu linkers?
Considerations include peptide length, steric accessibility of reactive sites, stability in plasma, and kinetics of intracellular cleavage to optimize therapeutic index and reduce off-target effects.
2/2/2021
Good morning! What storage and stability measures do you recommend for Fmoc-Gly-Gly-D-Phe-OtBu?
Fmoc-Gly-Gly-D-Phe-OtBu should be stored at -20°C under dry and light-protected conditions. Exposure to moisture should be avoided to prevent Fmoc or tBu deprotection. Aliquoting supports long-term stability, ensuring consistent performance in peptide synthesis and bioconjugation workflows.
7/9/2021
— Dr. Emily Carter, Senior Scientist (USA)
Fmoc-Gly-Gly-D-Phe-OtBu showed excellent stereochemical stability and high purity, enabling reproducible conjugation.
12/8/2017
— Prof. David Müller, Medicinal Chemist (Germany)
Batch-to-batch consistency of Fmoc-Gly-Gly-D-Phe-OtBu was outstanding, supporting reliable scale-up.
7/9/2021
— Dr. Anna Rossi, Bioconjugation Specialist (Italy)
BOC Sciences delivered Fmoc-Gly-Gly-D-Phe-OtBu with complete analytical documentation and on-time delivery.
2/2/2021
— Mr. James Thompson, R&D Manager (UK)
Using this peptide linker, we achieved efficient payload attachment and reproducible ADC yields.
13/5/2019
— Dr. Laura Jensen, ADC Project Lead (Denmark)
The linker improved workflow efficiency and reproducibility across multiple ADC projects.
— Ms. Sophie Martin, Senior Researcher (France)
High-quality Fmoc-Gly-Gly-D-Phe-OtBu facilitated smooth ADC development and screening.
17/12/2022
Fmoc-Gly-Gly-D-Phe-OtBu
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Fmoc-Gly-Gly-D-Phe-OtBu
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