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Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu (HY-44234).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01262 | -- | $-- | Inquiry |
Fmoc-Gly-Gly-D-Phe-OtBu, a versatile chemical compound, finds extensive applications in peptide synthesis and biochemical research. Here are four key applications of Fmoc-Gly-Gly-D-Phe-OtBu:
Peptide Synthesis: Serving as a fundamental component in solid-phase peptide synthesis, Fmoc-Gly-Gly-D-Phe-OtBu acts as a pivotal building block. Its Fmoc-protected N-terminal facilitates seamless peptide chain assembly, minimizing side reactions. This inherent property is indispensable for designing specific peptide sequences tailored for diverse research or therapeutic objectives.
Protein Engineering: Within the domain of protein engineering, this compound assumes a critical role in manipulating and investigating protein characteristics. By integrating specific amino acids like D-Phe, researchers can modulate protein folding, stability, and functionality. This strategic approach yields engineered proteins with desirable attributes, poised for applications in industrial or medical realms.
Pharmaceutical Development: In the realm of pharmaceutical research, Fmoc-Gly-Gly-D-Phe-OtBu holds notable significance, especially in the arena of drug design and development. Synthesized peptides utilizing this compound undergo rigorous testing for potential therapeutic actions such as enzyme inhibition or receptor binding. This process aids in identifying novel drug candidates and optimizing peptide-based therapeutics, fostering advancements in pharmaceutical science.
Chemical Biology: Within the interdisciplinary field of chemical biology, Fmoc-Gly-Gly-D-Phe-OtBu emerges as a pivotal tool for investigating biomolecular interactions. Researchers leverage this compound to synthesize peptides that interact with proteins, nucleic acids, or other biomolecules, enabling detailed exploration of biological mechanisms.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
