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CAS No.:
Cat No.: BADC-01221
Purity: ≥95%
4.5 
Azido-PEG1-Val-Cit-PABC-PNP is a reactive ADC linker featuring azide, valine-citrulline, and PABC for efficient enzymatic drug release. Supports click chemistry conjugation in precise ADC synthesis targeting tumor cells.
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Popular Publications Citing BOC Sciences Products
Azido-PEG1-Val-Cit-PABC-PNP is a linker used in the development of antibody-drug conjugates (ADCs) and other targeted therapies. Here are some key applications of Azido-PEG1-Val-Cit-PABC-PNP:
Antibody-Drug Conjugates (ADCs): Azido-PEG1-Val-Cit-PABC-PNP acts as a linker to attach cytotoxic drugs to antibodies that specifically target cancer cells. This ensures that the cytotoxic drug is delivered directly to cancer cells, minimizing off-target effects and maximizing therapeutic efficacy. The cleavable Val-Cit dipeptide linkage ensures that the drug is released within the target cells, enhancing the treatment’s precision.
Targeted Drug Delivery: By incorporating Azido-PEG1-Val-Cit-PABC-PNP into drug delivery systems, researchers can develop targeted therapies for various diseases. This linker can be conjugated with different ligands to create nanoparticles or other carriers that home in on specific tissues or cell types. This targeted approach helps to increase the therapeutic index by concentrating the drug action where it is needed most.
Bioconjugation Studies: Azido-PEG1-Val-Cit-PABC-PNP is employed in bioconjugation techniques to study protein-protein interactions and cellular uptake processes. Its azido group facilitates click chemistry reactions, allowing for the efficient conjugation of biomolecules. This makes it a valuable tool for creating complex bioconjugates used in diagnostics and research.
Controlled Drug Release: The Val-Cit linker within Azido-PEG1-Val-Cit-PABC-PNP is designed to be cleaved by enzymes present in certain tissues, making it useful for controlled drug release applications. This offers the potential for creating prodrugs that become active only in specific environments, such as the tumor microenvironment. Such controlled release systems can improve drug safety profiles and therapeutic outcomes.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01040 | Mal-PEG1-Val-Cit-PABC-OH | 2055041-37-5 | |
| 2565792-41-6 | [S(R)]-N-[(R)-[(3-(Benzyloxy)-2-(dicyclohexylphosphino)phenyl)phenylmethyl]-2-methyl-2-propanesulfinamide | 2565792-41-6 | |
| BADC-01342 | DBCO-C4-Val-Cit-PABC-PNP | ||
| BADC-01225 | BCN-PEG1-Val-Cit-PABC-OH | ||
| BADC-01256 | DBCO-Val-Cit-PABC-OH | ||
| BADC-01257 | DBCO-Val-Cit-PABC-PNP |
What is Azido-PEG1-Val-Cit-PABC-PNP and its significance in ADCs?
Azido-PEG1-Val-Cit-PABC-PNP is an enzyme-cleavable linker designed for site-specific ADC conjugation. The Val-Cit-PABC moiety allows intracellular release of payloads, and the azide group enables bioorthogonal click chemistry for efficient antibody attachment.
7/5/2019
Could you advise how Azido-PEG1-Val-Cit-PABC-PNP ensures selective payload release?
The Val-Cit dipeptide is cleaved by cathepsin B within lysosomes, triggering PABC self-immolation and releasing the cytotoxic drug only inside target cells. This mechanism reduces systemic toxicity.
27/8/2018
We are interested in which payloads are suitable for Azido-PEG1-Val-Cit-PABC-PNP.
It is compatible with a broad range of payloads containing amino or hydroxyl functional groups. The PNP ester chemistry enables efficient conjugation while preserving payload activity.
3/4/2022
Dear team, is Azido-PEG1-Val-Cit-PABC-PNP suitable for both in vitro and in vivo ADC studies?
Yes, its design supports controlled payload release in cellular models and in vivo systems, making it appropriate for preclinical efficacy, pharmacokinetics, and safety assessments.
6/8/2021
Dear team, what specifications are provided for Azido-PEG1-Val-Cit-PABC-PNP to support ADC conjugation?
Specifications for Azido-PEG1-Val-Cit-PABC-PNP include molecular weight confirmation, solubility profile, and recommended storage conditions. These parameters ensure reproducible conjugation to antibodies while maintaining linker stability under standard laboratory conditions.
7/2/2023
— Dr. Natalie Brown, Bioconjugation Scientist (USA)
Azido-PEG1-Val-Cit-PABC-PNP linker enabled efficient click chemistry conjugation with minimal by-products.
3/4/2022
— Prof. Henrik Larsen, Medicinal Chemist (Denmark)
Batch-to-batch consistency of Azido-PEG1-Val-Cit-PABC-PNP was excellent, supporting scale-up.
7/2/2023
— Dr. Sofia Moretti, Protein Chemist (Italy)
BOC Sciences’ linker showed high purity and reliable performance in conjugation.
6/8/2021
— Ms. Emily Thompson, R&D Manager (UK)
Using this linker, we achieved reproducible ADC yields and efficient payload attachment.
7/5/2019
— Dr. Marcus Schmidt, Bioconjugation Specialist (Germany)
Excellent solubility and reactivity of Azido-PEG1-Val-Cit-PABC-PNP improved workflow efficiency.
— Mr. Daniel Johnson, Research Scientist (Canada)
This linker consistently performed well in high-throughput screening and ADC development.
27/8/2018
Azido-PEG1-Val-Cit-PABC-PNP
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Azido-PEG1-Val-Cit-PABC-PNP
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