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DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01017 | -- | $-- | Inquiry |
DBCO-PEG5-acid, a versatile chemical linker with multifaceted uses in bioconjugation and biochemistry, boasts a range of applications:
Click Chemistry: At the forefront of chemical innovation, DBCO-PEG5-acid plays a pivotal role in click chemistry, particularly in the realm of strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. This chemical marvel facilitates the efficient and selective conjugation of biomolecules, such as proteins and nucleic acids, in the absence of copper catalysts. By enabling the creation of stable, covalently-linked bioconjugates, this method revolutionizes biochemical assays and therapeutic applications with unparalleled precision and reliability.
Drug Delivery Systems: In the realm of pharmaceuticals, DBCO-PEG5-acid emerges as a game-changer, enhancing the solubility and stability of drug delivery systems. Through the conjugation of DBCO-PEG5-acid with therapeutic molecules, researchers elevate the pharmacokinetic properties while reducing immunogenicity. This innovative approach not only enhances targeted drug delivery but also holds the promise of minimizing side effects and optimizing therapeutic outcomes.
Diagnostic Imaging: Harnessing the power of molecular imaging, DBCO-PEG5-acid serves as a key player in attaching imaging probes to specific targets within the body. Leveraging click chemistry, this compound facilitates the labeling of antibodies or peptides with fluorescent dyes or radiolabels, revolutionizing the precision and sensitivity of diagnostic imaging techniques. This advancement aids in early disease detection and monitoring, ushering in a new era of diagnostic accuracy and efficiency.
Surface Functionalization: In the domain of material science, DBCO-PEG5-acid shines bright as a tool for surface functionalization, rendering surfaces and materials amenable to a myriad of biological applications. Whether applied to nanoparticles, microarrays, or biosensors, DBCO-PEG5-acid enables the modification of surfaces with specific biological molecules. This tailored approach enhances interactions between modified surfaces and biological targets, boosting the performance and specificity of biosensing and diagnostic devices to new heights of effectiveness and efficiency.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
