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DBCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01073 | -- | $-- | Inquiry |
DBCO-PEG5-NHS ester, a versatile reagent in bioconjugation techniques, plays a pivotal role in linking molecules for diverse biomedical applications. Here are four key applications:
Site-Specific Protein Labeling: Leveraging DBCO-PEG5-NHS ester in bioorthogonal click chemistry enables precise labeling of proteins at specific sites through targeting distinct amino acid residues. This reagent facilitates the attachment of fluorescent dyes or other probes, essential for investigating protein interactions and cellular localization with intricacy and detail.
Drug Delivery Research: In the realm of drug delivery, DBCO-PEG5-NHS ester serves as a crucial tool for conjugating therapeutic agents to targeting moieties like antibodies or peptides. This conjugation enhances the precision and effectiveness of drug delivery systems, enabling targeted treatment of diseases such as cancer. PEGylation further aids in reducing immunogenicity and prolonging circulation time in vivo.
Biomaterial Functionalization: Within the domain of biomaterials, DBCO-PEG5-NHS ester finds utility in functionalizing surfaces with bioactive molecules, thereby enhancing the biocompatibility and functionality of implants or medical devices. By attaching peptides, proteins, or other bioactive ligands, this reagent fosters improved integration with biological tissues and augments therapeutic outcomes, marking a significant advancement in biomaterial engineering.
Diagnostic Assay Development: In the development of diagnostic assays, DBCO-PEG5-NHS ester plays a pivotal role, particularly in capturing and detecting biomolecules with precision. Through linking capture antibodies or antigens to solid supports, this reagent elevates the sensitivity and specificity of assays, crucial in applications like enzyme-linked immunosorbent assays (ELISA) and biosensors.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
