Name: ICG-alkyne
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

ICG alkyne; 4-(2-(7-(1,1-dimethyl-3-(6-oxo-6-(prop-2-yn-1-ylamino)hexyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate

IUPAC Name

4-[(2Z)-2-[(2E,4E,6E)-7-[1,1-dimethyl-3-[6-oxo-6-(prop-2-ynylamino)hexyl]benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate

Canonical SMILES

CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)CCCCCC(=O)NCC#C)C=CC=CC=CC=C4C(C5=C(N4CCCCS(=O)(=O)[O-])C=CC6=CC=CC=C65)(C)C)C

InChI

InChI=1S/C48H53N3O4S/c1-6-32-49-44(52)27-13-10-18-33-50-40-30-28-36-21-14-16-23-38(36)45(40)47(2,3)42(50)25-11-8-7-9-12-26-43-48(4,5)46-39-24-17-15-22-37(39)29-31-41(46)51(43)34-19-20-35-56(53,54)55/h1,7-9,11-12,14-17,21-26,28-31H,10,13,18-20,27,32-35H2,2-5H3,(H-,49,52,53,54,55)

InChIKey

XXTDAEMDSXMISJ-UHFFFAOYSA-N

Appearance

Green Powder

ICG-alkyne, a dye infused with the properties of indocyanine green (ICG) and an alkyne group, boasts a wide array of applications in advanced bioimaging and chemical biology.

Fluorescence Imaging: Recognized for its extensive usage in near-infrared fluorescence imaging, ICG-alkyne stands out in the realms of medical diagnostics and research. Its unique near-infrared fluorescence capabilities allow for deep tissue imaging with minimal background interference, facilitating the precise visualization of vascular structures, tumors, and various biological tissues in vivo.

Bioorthogonal Chemistry: With its alkyne group facilitating involvement in click chemistry reactions, ICG-alkyne emerges as a versatile asset for conjugating with a plethora of biomolecules. This characteristic renders it indispensable for labeling and tracking proteins, nucleic acids, and other cellular components essential for unraveling dynamic biological processes and molecular interactions.

Surgical Guidance: Employed in image-guided surgery, ICG-alkyne enhances the visualization of tumors and crucial anatomical structures, assisting surgeons in distinguishing between healthy and diseased tissues with heightened precision. Leveraging the fluorescent attributes of ICG-alkyne, this technology aims to reduce invasiveness and enhance patient outcomes through improved surgical accuracy.

Theranostics: Blending therapeutic and diagnostic functionalities, ICG-alkyne plays a pivotal role in theranostic applications, catering to both the treatment and monitoring of diseases concurrently. By conjugating the dye with therapeutic agents for targeted delivery to specific tissues or cells and utilizing its fluorescence for real-time tracking of treatment efficacy, this comprehensive approach optimizes treatment strategies and customizes patient care for enhanced outcomes.