Name: DBCO-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

Azadibenzocyclooctyne-amine

IUPAC Name

Canonical SMILES

C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCN

InChI

InChI=1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2

InChIKey

OCCYFTDHSHTFER-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Melting Point

86-96 °C

PSA

46.33000

Appearance

Slightly yellow to slightly crystalline

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C

Signal Word

Warning

DBCO-amine, a highly versatile chemical widely utilized in bioconjugation and molecular biology, offers a myriad of applications.

Bioconjugation: Known for facilitating the formation of stable covalent bonds between biomolecules, DBCO-amine employs its strain-promoted azide-alkyne cycloaddition (SPAAC) reaction to intricately attach to azide-modified molecules without relying on copper catalysts. This unique feature renders it an indispensable tool for labeling proteins, nucleic acids, and other biomolecules across various research and diagnostic realms, showcasing its versatility and efficiency.

Drug Delivery: In the realm of drug delivery, DBCO-amine plays a pivotal role in conjugating therapeutic agents to targeting moieties like antibodies or peptides, thereby enhancing the precision and effectiveness of drug delivery systems. This strategic attachment ensures the precise delivery of therapeutic compounds to their intended cellular targets, ultimately enhancing the therapeutic index and minimizing off-target effects.

Bioorthogonal Chemistry: As a cornerstone reagent in bioorthogonal chemistry, DBCO-amine enables researchers to conduct chemical reactions within living organisms without disrupting native biochemical processes. This unique property is harnessed to produce labeled biomolecules for in vivo imaging studies, providing real-time insights into biological processes. Such cutting-edge applications are essential for advancing our comprehension of intricate biological systems and disease pathologies, offering a window into the inner workings of living organisms.

Surface Modification: Utilized in the surface modification of nanoparticles and biosensors, DBCO-amine facilitates the attachment of functional biomolecules to improve performance. Through the covalent linking of biomolecules to surfaces, researchers can enhance the sensitivity and specificity of diagnostic devices or innovate novel materials for biomedical applications. This innovative approach propels the development of sophisticated detection systems and therapeutic platforms, setting new standards for bioengineering advancements.