1-BOC-Azetidine-3-carboxylic acid methyl ester - CAS610791-05-4 Catalog number: BADC-01925
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1-BOC-Azetidine-3-carboxylic acid methyl ester - CAS610791-05-4 Catalog number: BADC-01925

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1-BOC-Azetidine-3-carboxylic acid methyl ester is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.

Category
ADCs Linker
Product Name
1-BOC-Azetidine-3-carboxylic acid methyl ester
CAS
610791-05-4
Catalog Number
BADC-01925
Molecular Formula
C10H17NO4
Molecular Weight
215.25
1-BOC-Azetidine-3-carboxylic acid methyl ester

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BADC-01925 -- $--
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Description
1-BOC-Azetidine-3-carboxylic acid methyl ester is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
Synonyms
Methyl 1-Boc-azetidine-3-carboxylate; 1-tert-butyl 3-methyl azetidine-1,3-dicarboxylate
IUPAC Name
1-O-tert-butyl 3-O-methyl azetidine-1,3-dicarboxylate
Canonical SMILES
CC(C)(C)OC(=O)N1CC(C1)C(=O)OC
InChI
InChI=1S/C10H17NO4/c1-10(2,3)15-9(13)11-5-7(6-11)8(12)14-4/h7H,5-6H2,1-4H3
InChIKey
SECFRXGVLMVUPD-UHFFFAOYSA-N
Density
1.2±0.1 g/cm3
Purity
>95%
Boiling Point
269.0±33.0 °C at 760 mmHg
1.HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia.
Baskaran G1, Salvamani S1, Ahmad SA1, Shaharuddin NA1, Pattiram PD2, Shukor MY1. Drug Des Devel Ther. 2015 Jan 14;9:509-17. doi: 10.2147/DDDT.S75056. eCollection 2015.
The enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase is the key enzyme of the mevalonate pathway that produces cholesterol. Inhibition of HMG-CoA reductase reduces cholesterol biosynthesis in the liver. Synthetic drugs, statins, are commonly used for the treatment of hypercholesterolemia. Due to the side effects of statins, natural HMG-CoA reductase inhibitors of plant origin are needed. In this study, 25 medicinal plant methanol extracts were screened for anti-HMG-CoA reductase activity. Basella alba leaf extract showed the highest inhibitory effect at about 74%. Thus, B. alba was examined in order to investigate its phytochemical components. Gas chromatography with tandem mass spectrometry and reversed phase high-performance liquid chromatography analysis revealed the presence of phenol 2,6-bis(1,1-dimethylethyl), 1-heptatriacotanol, oleic acid, eicosyl ester, naringin, apigenin, luteolin, ascorbic acid, and α-tocopherol, which have been reported to possess antihypercholesterolemic effects.
2.[GC-MS analysis of the fatty components of pollen Typhae before and after being carbonized].
Ma HF1, Liu B, Zhang GY, Shi RB, Ma CH, Yu MM. Zhongguo Zhong Yao Za Zhi. 2006 Feb;31(3):200-2.
OBJECTIVE: To study the changes of the fatty components of Pollen Typhae before and after being carbonized.
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Historical Records: Me-Tet-PEG8-NH2 hydrochloride | 1-BOC-Azetidine-3-carboxylic acid methyl ester
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