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Azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01920 | -- | $-- | Inquiry |
Azetidine-3-carboxylic acid is a cyclic amino acid with a unique structure that offers several promising applications in scientific research and industry. Here are some key applications of Azetidine-3-carboxylic acid:
Peptide Synthesis: Azetidine-3-carboxylic acid is utilized in the synthesis of cyclic peptides, which have enhanced stability and bioavailability compared to linear peptides. These cyclic peptides can be used in drug development to improve therapeutic properties and target specificity. By incorporating Azetidine-3-carboxylic acid, researchers can design peptides with unique structural features that are resistant to degradation.
Protein Structure Studies: The introduction of Azetidine-3-carboxylic acid into protein sequences provides a tool for studying protein folding and stability. Its rigid cyclic structure can induce conformational constraints, aiding in the examination of protein folding pathways and the identification of key stabilizing interactions. This application is crucial for understanding protein dynamics and engineering more stable protein therapeutics.
Antibacterial Research: Azetidine-3-carboxylic acid derivatives have been investigated for their potential antibacterial properties. By modifying its structure, researchers aim to develop novel antimicrobial agents that can inhibit bacterial growth and combat antibiotic-resistant strains. This application holds significant promise in addressing the growing public health concern of antibiotic resistance.
Material Science: Azetidine-3-carboxylic acid is used to create innovative materials with unique mechanical and chemical properties. Its incorporation into polymer matrices can enhance the material's thermal stability, mechanical strength, and resistance to environmental degradation. This makes it valuable for applications in the development of advanced materials for industrial and biomedical purposes.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
