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Gly-NH-CH2-Boc is a cleavable ADC linker that can be used in antibody-conjugated active molecules (ADC).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01627 | -- | $-- | Inquiry |
Gly-NH-CH2-Boc, also recognized as N-Boc-glycine methyl ester, stands as a versatile compound with wide-ranging applications in organic synthesis and biotechnological endeavors.
Peptide Synthesis: A staple in peptide synthesis, Gly-NH-CH2-Boc emerges as a frequently employed protected glycine derivative. The Boc (tert-butoxycarbonyl) group acts as a shield for the amino group during peptide chain elongation, averting undesired side reactions. This enables the precise and selective assembly of peptides with custom sequences and functionalities, exemplifying the finesse of organic synthesis.
Pharmaceutical Development: Pioneering drug discovery, Gly-NH-CH2-Boc plays a pivotal role as a fundamental building block for crafting biologically active molecules and pharmaceutical intermediates. Through the integration of this safeguarded amino acid into drug candidates, researchers delve into the intricate structure-activity relationships crucial for designing and enhancing novel therapeutic agents.
Bioconjugation: Embracing bioconjugation strategies, Gly-NH-CH2-Boc proves instrumental in attaching functional molecules to biomolecules like proteins or antibodies. The Boc group, known for its ease of removal under mild conditions, liberates the amino group for subsequent chemical alterations.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
