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CAS No.: 14664-05-2
Cat No.: BADC-01627
4.5 
Gly-NH-CH2-Boc is a Boc-protected glycine derivative ADC linker intermediate designed for site-specific payload conjugation and enhanced stability in antibody-drug conjugates. Keywords: ADC linker, glycine linker, Boc protection, payload attachment, bioconjugation.
Structure of 14664-05-2
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Gly-NH-CH2-Boc, also recognized as N-Boc-glycine methyl ester, stands as a versatile compound with wide-ranging applications in organic synthesis and biotechnological endeavors.
Peptide Synthesis: A staple in peptide synthesis, Gly-NH-CH2-Boc emerges as a frequently employed protected glycine derivative. The Boc (tert-butoxycarbonyl) group acts as a shield for the amino group during peptide chain elongation, averting undesired side reactions. This enables the precise and selective assembly of peptides with custom sequences and functionalities, exemplifying the finesse of organic synthesis.
Pharmaceutical Development: Pioneering drug discovery, Gly-NH-CH2-Boc plays a pivotal role as a fundamental building block for crafting biologically active molecules and pharmaceutical intermediates. Through the integration of this safeguarded amino acid into drug candidates, researchers delve into the intricate structure-activity relationships crucial for designing and enhancing novel therapeutic agents.
Bioconjugation: Embracing bioconjugation strategies, Gly-NH-CH2-Boc proves instrumental in attaching functional molecules to biomolecules like proteins or antibodies. The Boc group, known for its ease of removal under mild conditions, liberates the amino group for subsequent chemical alterations.
Gly-NH-CH2-Boc
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Gly-NH-CH2-Boc
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