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CAS No.: 955094-26-5
Cat No.: BADC-00447
Purity: ≥98%
4.5 
Mal-amido-PEG2-NHS is a PEG-containing maleimide conjugation reagent designed for thiol-reactive coupling. The maleimide group provides a selective handle for sulfhydryl-containing molecules, while the opposite terminus and spacer determine how the reagent can be connected to a payload, linker intermediate, or additional functional module. The molecule incorporates peg2 spacer and provides opposite-end functionality not fully defined from the name; maleimide itself is typically reserved for antibody thiol conjugation on the opposite side. It can be used in stepwise conjugation workflows that combine thiol-maleimide coupling with an orthogonal second reaction, with reaction order selected to suit the stability and accessibility of each functional group.
Structure of 955094-26-5
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Mal-amido-PEG2-NHS is a chemical linker commonly used in the field of bioconjugation and drug delivery. Here are some key applications of Mal-amido-PEG2-NHS:
Bioconjugation: Mal-amido-PEG2-NHS is widely used for conjugating proteins, antibodies, or peptides with other molecules, such as drugs or fluorescent dyes. The NHS ester group reacts with primary amines, while the maleimide group targets thiols, ensuring stable and specific linkage. This is critical for developing targeted drug delivery systems and diagnostic tools in research and clinical settings.
Drug Delivery Systems: In drug delivery, Mal-amido-PEG2-NHS helps in modifying therapeutic agents to improve their solubility, stability, and bioavailability. The PEG (polyethylene glycol) component enhances the drug's pharmacokinetic properties by reducing immunogenicity and prolonging circulation time. This linker can be used to attach drugs to carrier molecules, enabling controlled release and targeted therapy.
Surface Modification: Mal-amido-PEG2-NHS is employed to modify surfaces of biomaterials and medical devices, providing a hydrophilic and biocompatible layer. This modification reduces protein adsorption and cell adhesion, minimizing undesirable immune responses and improving device performance. Such surface engineering applications are essential for implants and biosensors.
Crosslinking: In biopolymer chemistry, Mal-amido-PEG2-NHS is used for crosslinking molecules within hydrogels and other polymer matrices. The controlled crosslinking capability allows for tuning the mechanical and physical properties of the materials, making them suitable for tissue engineering and regenerative medicine applications. This approach supports the development of scaffolds that mimic natural tissue environments.
Mal-amido-PEG2-NHS
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Mal-amido-PEG2-NHS
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