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Mal-amido-(CH2COOH)2

  CAS No.: 207613-14-7   Cat No.: BADC-01052   Purity: >98.0% 4.5  

Mal-amido-(CH2COOH)2 is a maleimide-based ADC linker featuring carboxylic acid groups, supporting selective cysteine conjugation and enhanced solubility for efficient antibody-drug conjugate synthesis.

Mal-amido-(CH2COOH)2

Structure of 207613-14-7

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Category
ADC Linker
Molecular Formula
C11H12N2O7
Molecular Weight
284.22
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
[3-(2,5-Dioxo-3-pyrroline-1-yl)propionylimino]diacetic acid
IUPAC Name
2-[carboxymethyl-[3-(2,5-dioxopyrrol-1-yl)propanoyl]amino]acetic acid
Canonical SMILES
C1=CC(=O)N(C1=O)CCC(=O)N(CC(=O)O)CC(=O)O
InChI
InChI=1S/C11H12N2O7/c14-7(12(5-10(17)18)6-11(19)20)3-4-13-8(15)1-2-9(13)16/h1-2H,3-6H2,(H,17,18)(H,19,20)
InChIKey
WGKBLBPWMDGTDE-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid

Mal-amido-(CH2COOH)2, also known as maleyl amido acid, is a versatile compound with diverse applications across scientific and industrial domains.

Polymer Chemistry: Mal-amido-(CH2COOH)2 serves as a crucial building block for crafting specialty polymers. By integrating this compound into polymeric structures, scientists tailor materials with specific attributes like flexibility, hydrophilicity, or biodegradability. These custom-designed polymers find utility across industries spanning from packaging to cutting-edge biomedical devices.

Drug Delivery Systems: Mal-amido-(CH2COOH)2 emerges as a valuable linker in creating targeted drug delivery systems. Conjugating therapeutic agents to this compound results in the formulation of prodrugs that release active compounds in a controlled fashion. Such precisely targeted systems amplify drug efficacy while mitigating unwanted side effects.

Bioconjugation: Mal-amido-(CH2COOH)2 takes center stage in protein and peptide modification through bioconjugation processes. Leveraging this compound, researchers functionalize proteins with diverse chemical groups, enabling in-depth exploration of protein interactions and functionalities. This transformative technique underpins the development of cutting-edge biosensors, diagnostic tools, and therapeutic proteins.

Catalysis: Unveiling its prowess as a potent chelating agent, Mal-amido-(CH2COOH)2 catalyzes chemical reactions through complexation with metal ions to augment catalytic activity. These metal complexes catalyze a spectrum of reactions, including oxidations and hydrolyses, enhancing chemical synthesis efficiency and selectivity.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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