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Fmoc-PEG4-Ala-Ala-Asn-PAB is a cleavable 4-unit PEG peptide linker that is used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01049 | -- | $-- | Inquiry |
Fmoc-PEG4-Ala-Ala-Asn-PAB is a specialized compound utilized in advanced peptide synthesis and drug development applications. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the N-terminus, enabling controlled peptide chain elongation through solid-phase peptide synthesis (SPPS). This compound combines the hydrophilic PEG4 (tetraethylene glycol) spacer with the Ala-Ala-Asn tripeptide sequence and a para-aminobenzyl (PAB) moiety, making it a versatile building block for constructing functionalized peptides and bioconjugates.
The PEG4 spacer in Fmoc-PEG4-Ala-Ala-Asn-PAB introduces flexibility and solubility to the compound, enhancing the pharmacokinetic properties of peptide conjugates. This hydrophilic segment helps reduce aggregation and improves the stability of peptide-based drugs in aqueous environments. As a result, Fmoc-PEG4-Ala-Ala-Asn-PAB is widely used in the design of peptide-drug conjugates (PDCs) and antibody-drug conjugates (ADCs), where it facilitates the attachment of cytotoxic agents, imaging probes, or targeting ligands. This functionality is particularly beneficial in precision medicine, allowing for targeted drug delivery and reduced off-target effects.
The Ala-Ala-Asn sequence in Fmoc-PEG4-Ala-Ala-Asn-PAB is significant for creating linkers or substrates in protease-sensitive drug delivery systems. This sequence can be engineered to serve as a recognition site for specific enzymes, enabling controlled drug release in target tissues, such as tumors or inflamed regions. Such enzyme-responsive linkers are essential in developing prodrugs and ADCs that activate their therapeutic payloads only in disease-specific environments, minimizing systemic toxicity.
The PAB (para-aminobenzyl) group is another key feature of Fmoc-PEG4-Ala-Ala-Asn-PAB, acting as a self-immolative linker. After enzymatic cleavage of the tripeptide sequence, the PAB moiety undergoes rapid decomposition, releasing the attached drug or bioactive molecule. This unique property makes the compound highly valuable in designing cleavable linkers for ADCs and PDCs, enabling precise and efficient release of therapeutic agents at the desired site of action.
Fmoc-PEG4-Ala-Ala-Asn-PAB is also used in the synthesis of biofunctionalized surfaces and biomaterials. The PEG4 segment ensures compatibility with biological systems, while the peptide sequence and PAB moiety enable the controlled release of immobilized bioactive molecules. These characteristics make the compound an essential tool in drug delivery, biosensing, and the development of smart materials for biomedical applications.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
