Sudemycin E - CAS 1197054-49-1

Sudemycin E - CAS 1197054-49-1 Catalog number: BADC-00785

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a potent pre-mRNA splicing inhibitor. Sudemycin E is an analog of the natural product FR901464 and show a potent inhibit activity of cancer cell lines.

Category
ADCs Cytotoxin
Product Name
Sudemycin E
CAS
1197054-49-1
Catalog Number
BADC-00785
Molecular Formula
C27H41NO7
Molecular Weight
491.63
Sudemycin E

Ordering Information

Catalog Number Size Price Quantity
BADC-00785 -- $--
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Description
a potent pre-mRNA splicing inhibitor. Sudemycin E is an analog of the natural product FR901464 and show a potent inhibit activity of cancer cell lines.
In Vitro
Sudemycin E causes the death of cancer cells through an unknown mechanism. Similar to spliceostatin A, sudemycin E binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1. Native chromatin immunoprecipitations showed that U2 snRNPs physically interact with nucleosomes. Sudemycin E induces a dissociation of the U2 snRNPs and decreases their interaction with nucleosomes. Sudemycin E first causes a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes in overall gene expression and arrest in the G2 phase of the cell cycle. The changes in alternative exon usage correlate with a loss of the H3K36me3 modification in chromatin encoding these exons.
Shipping
Room temperature, or blue ice upon request.
Storage
-20°C
The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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