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m-PEG9-NHS ester is a PEG derivative containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media. m-PEG9-NHS ester is a linker for antibody-drug-conjugation (ADC).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00583 | -- | $-- | Inquiry |
mPEG9-NHS ester, a versatile reagent in bioconjugation and drug delivery, offers efficiency and adaptability in various applications. Here are four key applications of mPEG9-NHS ester:
Protein Pegylation: Embracing the prowess of mPEG9-NHS ester, scientists embark on the pegylation of proteins, a process characterized by the attachment of polyethylene glycol (PEG) chains to proteins for heightened solubility, stability, and extended half-life. This modification not only diminishes immunogenicity but also augments therapeutic efficacy by mitigating rapid degradation and clearance, thereby elevating the utility of pegylated proteins in the realm of pharmaceuticals.
Surface Modification: Enter the world of surface modification, where mPEG9-NHS ester reigns supreme, enhancing the biocompatibility of nanoparticles and biomaterials while curbing non-specific binding tendencies. Through the attachment of PEG chains to surfaces, a hydrophilic shield is crafted, minimizing undesired protein adsorption and cellular interactions. This strategy is pivotal in sculpting drug delivery systems and biomedical implants, propelling performance enhancements and mitigating immune responses.
Antibody Conjugation: Witness the transformative impact of mPEG9-NHS ester in the conjugation of antibodies to PEG, a process that elevates the pharmacokinetics and therapeutic potential of antibody-based medications. Pegylation of antibodies extends their circulation time in the bloodstream, ushering in prolonged therapeutic effects. This application holds particular significance in the realm of cancer therapy, contributing to the development of antibody-drug conjugates (ADCs) poised to revolutionize treatment approaches.
Diagnostic Imaging: Journey into the realm of diagnostic imaging, where mPEG9-NHS ester plays a pivotal role in refining imaging agents for heightened efficacy. By attaching PEG to imaging molecules, researchers elevate solubility, stability, and distribution characteristics, culminating in enhanced imaging clarity and precision. This enhancement proves indispensable in diagnostic modalities like MRI and PET scans, where superior imaging agents bolster the accurate detection and monitoring of diseases.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
