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CAS No.: 1449390-12-8
Cat No.: BADC-00954
Purity: >98.0%
4.5 
mPEG6-NHS ester is a PEG linker with a reactive NHS ester group used for amine coupling in ADC synthesis. The PEG6 spacer increases hydrophilicity, ensuring stable payload conjugation and improved pharmacokinetic behavior of antibody-drug conjugates.
Structure of 1449390-12-8
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Popular Publications Citing BOC Sciences Products
mPEG6-NHS ester, a versatile reagent in bioconjugation and surface modification, is utilized across protein chemistry and biotechnology for a myriad of applications.
Protein and Peptide Modification: Positioned as a cornerstone in protein engineering, mPEG6-NHS ester emerges as a pivotal player for augmenting the solubility, stability, and biocompatibility of proteins and peptides. Through strategic conjugation with amino groups on lysine residues, researchers cloak proteins to shield them from immunogenic responses.
Surface Coating: In the realm of advancing biomaterials, mPEG6-NHS ester assumes a critical role in surface engineering, particularly in the coating of medical devices and implants to mitigate protein adsorption and cell adhesion. This innovative PEGylation strategy erects a hydrophilic barricade to curb fouling and enhance surface biocompatibility, thereby prolonging the functionality and longevity of implanted biomedical equipment.
Drug Delivery: Embarking on the journey towards optimized drug delivery systems, mPEG6-NHS ester shines as a linchpin in the modification of nanoparticles and liposomes. By skillfully PEGylating the carrier surface, scientists prolong circulation time in the bloodstream, elevating drug stability and bioavailability.
Diagnostic Applications: Within diagnostic realms, mPEG6-NHS ester assumes a pivotal role in amplifying the precision and reliability of assays by conjugating PEG chains to antibodies and detection molecules. This strategic modification diminishes nonspecific binding, amplifying sensitivity and accuracy in assays such as ELISAs.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00512 | m-PEG1-NHS ester | 1027371-75-0 | |
| BADC-00519 | m-PEG2-NHS ester | 1127247-34-0 | |
| BADC-00583 | mPEG9-NHS ester | 1316189-13-5 | |
| BADC-00702 | m-PEG3-NHS ester | 876746-59-7 |
mPEG6-NHS ester
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mPEG6-NHS ester
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