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Mal-PEG4-NHS

  CAS No.: 1325208-25-0   Cat No.: BADC-00450   Purity: ≥98% 4.5  

Mal-PEG4-NHS is a heterobifunctional ADC linker that combines maleimide and NHS ester functionalities, enabling thiol and amine conjugation. The PEG4 spacer enhances hydrophilicity and biocompatibility, ideal for stable antibody-drug conjugation.

Mal-PEG4-NHS

Structure of 1325208-25-0

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ADC Linker
Molecular Formula
C19H26N2O10
Molecular Weight
442.42
Shipping
Room temperature
Shipping
Store at 2-8°C under inert gas (nitrogen or argon)

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
Mal-PEG4-NHS ester; 2,5-dioxopyrrolidin-1-yl 1-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-3,6,9,12-tetraoxapentadecan-15-oate; 4,7,10,13-Tetraoxapentadecanoic acid, 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,5-dioxo-1-pyrrolidinyl ester; 2,5-dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecan-15-oate; 1-{15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-1H-pyrrole-2,5-dione; 1H-Pyrrole-2,5-dione, 1-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCN2C(=O)C=CC2=O
InChI
InChI=1S/C19H26N2O10/c22-15-1-2-16(23)20(15)6-8-28-10-12-30-14-13-29-11-9-27-7-5-19(26)31-21-17(24)3-4-18(21)25/h1-2H,3-14H2
InChIKey
TUPOSLKVPPFQGR-UHFFFAOYSA-N
Density
1.36±0.1 g/cm3 (Predicted)
Solubility
Soluble in DCM, DMSO
Appearance
Light Yellow Oily Matter
Shipping
Room temperature
Storage
Store at 2-8°C under inert gas (nitrogen or argon)
Boiling Point
580.5±60.0°C (Predicted)

Mal-PEG4-NHS is a highly reactive bioconjugation reagent used extensively in drug delivery, protein labeling, and targeted therapies. The maleimide (Mal) group facilitates efficient conjugation with thiol-containing molecules, such as peptides, proteins, and antibodies, while the NHS (N-hydroxysuccinimide) ester reacts with primary amines, allowing for versatile functionalization. The PEG4 spacer provides enhanced solubility, stability, and pharmacokinetics, improving the conjugate’s in vivo performance. This compound is widely used in the design of antibody-drug conjugates (ADCs), targeted delivery systems, and biomolecule labeling for research and therapeutic applications.

A key application of Mal-PEG4-NHS is in the development of antibody-drug conjugates (ADCs) for cancer therapy. By linking cytotoxic drugs or therapeutic agents to monoclonal antibodies through the maleimide group, this conjugate enables the selective delivery of drugs to tumor cells that express specific surface antigens. The PEG4 spacer improves the pharmacokinetics of the conjugate, increasing its solubility and circulation time, which ensures better distribution throughout the body. The NHS ester allows for the addition of targeting ligands or further functionalization with other biomolecules, such as imaging agents, for dual-targeting or monitoring of therapeutic efficacy. This targeted approach improves the therapeutic index by enhancing the drug’s efficacy at the tumor site while minimizing off-target effects.

Mal-PEG4-NHS is also widely used in protein and peptide labeling for research and diagnostic applications. The NHS ester reacts with primary amines on proteins, peptides, or other biomolecules, enabling the covalent attachment of fluorescent dyes, enzymes, or other functional groups. The PEG4 spacer ensures that the conjugated biomolecule maintains solubility and stability in aqueous environments, reducing aggregation and improving its overall functionality. This makes Mal-PEG4-NHS an ideal reagent for applications in flow cytometry, immunoassays, and live-cell imaging, where precise labeling of biomolecules is critical for tracking cellular processes or studying molecular interactions.

Another important application of Mal-PEG4-NHS is in the creation of targeted drug delivery systems. By conjugating therapeutic agents to targeting ligands, such as antibodies or peptides, via the NHS ester, Mal-PEG4-NHS enables the specific delivery of drugs to designated cells or tissues. The PEG4 spacer enhances the pharmacokinetics and bioavailability of the conjugate, ensuring better drug release profiles and reducing systemic toxicity. This approach is particularly useful in the development of personalized medicine, where drugs can be tailored to target specific molecular markers or receptors found on cancer cells or other diseased tissues, providing more effective treatment options.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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