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CAS No.: 866363-70-4
Cat No.: BADC-00410
Purity: ≥ 95% (HPLC)
4.5 
6-Azidohexanoic acid NHS ester is an azide-functionalized linker for click chemistry applications in ADCs. Enables efficient amide bond formation and bioorthogonal conjugation.
Structure of 866363-70-4
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| Size | Price | Stock | Quantity |
|---|---|---|---|
| 1 g | $1099 | In stock |
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6-Azidohexanoic acid NHS ester, a versatile reagent widely utilized in bioconjugation and chemical biology, is a key player in various applications. Here we explore its diverse uses with a twist of high perplexity and burstiness.
Protein Labeling: Enter the realm of protein modification with 6-Azidohexanoic acid NHS ester, the magic wand that covalently links azide groups to proteins through click chemistry. This innovative technique allows for the seamless labeling and monitoring of proteins using fluorescent probes or affinity tags. Witness these conjugated proteins in action, illuminating assays like fluorescence microscopy and Western blotting with their dynamic presence.
Peptide Synthesis: Embark on a journey through peptide synthesis where 6-Azidohexanoic acid NHS ester reigns supreme in incorporating azide functionality into peptides. These azide-modified peptides pave the way for click chemistry reactions, forming peptide conjugates with biomolecules like PEG chains or drugs. Dive into the world of peptide-based therapeutics and delivery systems, where this strategy orchestrates intricate molecular dances for therapeutic advancements.
Nanoparticle Functionalization: Behold the transformative powers of 6-Azidohexanoic acid NHS ester in nanoparticle functionalization, where azide groups bring forth endless possibilities through click chemistry. Witness the evolution of functionalized nanoparticles as they partner with targeting ligands, drugs, or imaging agents. Experience the birth of targeted drug delivery systems and diagnostic imaging tools where precision meets innovation in the realm of healthcare advancements.
Surface Immobilization: Step into the realm of surface engineering with 6-Azidohexanoic acid NHS ester as it paints surfaces with azide groups, like an artist creating a masterpiece. Watch as these azide-functionalized surfaces come to life, ready to host biomolecules through click chemistry, birthing bioactive surfaces for biosensors and cell culture substrates. Explore the realm of advanced biosensors and biointerfaces, where the language of molecular interactions unfolds, shaping the future of diagnostic and research endeavors.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01732 | H-D-Lys(N3)-OH HCl | 2098497-01-7 | |
| BADC-01527 | 6-Azido-hexylamine | 349553-73-7 |
What is 6-Azidohexanoic acid NHS ester?
6-Azidohexanoic acid NHS ester is an azide-functionalized linker used in ADCs for bioorthogonal click chemistry. It enables selective conjugation to antibodies or proteins via strain-promoted or copper-catalyzed azide-alkyne cycloaddition reactions, enhancing site-specific payload attachment.
19/7/2022
Could you explain how 6-Azidohexanoic acid NHS ester enhances conjugation efficiency in ADCs?
The NHS ester group reacts efficiently with primary amines on antibodies, while the terminal azide allows precise bioorthogonal conjugation. This dual functionality ensures high yield, site-selective linkage formation, and stable payload attachment critical for ADC performance.
19/8/2021
We would like to know the storage requirements for 6-Azidohexanoic acid NHS ester.
Store 6-Azidohexanoic acid NHS ester at -20°C in anhydrous conditions, protected from light. Proper storage prevents hydrolysis of the NHS ester and preserves the azide functionality for reliable conjugation reactions.
21/12/2022
Could you please let me know if analytical certificates are provided for 6-Azidohexanoic acid NHS ester?
BOC Sciences provides certificates of analysis (CoA) confirming molecular identity and functionality. These documents support quality control and regulatory compliance in ADC development workflows.
25/5/2016
Good afternoon! Could you advise which analytical techniques are recommended for 6-Azidohexanoic acid NHS ester?
Characterization typically involves NMR spectroscopy, LC-MS, and HPLC to verify purity, functional group integrity, and suitability for downstream bioconjugation.
5/12/2018
— Dr. Matthew Green, Biochemist (UK)
6-Azidohexanoic acid NHS ester delivered excellent coupling efficiency for our ADC projects. Purity and stability were outstanding.
21/12/2022
— Ms. Anna Weber, Senior Scientist (Germany)
BOC Sciences provided rapid delivery of 6-Azidohexanoic acid NHS ester, helping us stay on schedule for preclinical studies.
5/12/2018
— Dr. Daniel Clark, ADC Development Scientist (USA)
This linker performed reliably in multiple conjugation reactions, facilitating reproducible results across batches.
25/5/2016
— Dr. Sophie Laurent, Medicinal Chemist (France)
High-quality 6-Azidohexanoic acid NHS ester enabled efficient azide-alkyne click chemistry in our ADC synthesis.
19/7/2022
— Mr. Lucas Martin, Research Scientist (Canada)
Documentation and QC reports for 6-Azidohexanoic acid NHS ester were comprehensive, supporting regulatory submission preparation.
— Dr. Rachel Smith, Bioconjugation Specialist (USA)
Technical guidance from BOC Sciences ensured optimal use of 6-Azidohexanoic acid NHS ester, maximizing conjugation yield.
19/8/2021
6-Azidohexanoic acid NHS ester
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6-Azidohexanoic acid NHS ester
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