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6-Azido-hexylamine

  CAS No.: 349553-73-7   Cat No.: BADC-01527   Purity: >95% 4.5  

6-Azido-hexylamine is a highly versatile cleavable linker widely used in biomedical fields. This compound is known for its key role in advancing targeted therapeutic release mechanisms and bioconjugation approaches that can significantly enhance the ability to fight a range of diseases including cancer, infectious diseases and neurological diseases.

6-Azido-hexylamine

Structure of 349553-73-7

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Category
ADC Linker
Molecular Formula
C6H14N4
Molecular Weight
142.20

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
6-azidohexan-1-amine; 6-AZIDO-HEXYLAMINE; 6-Azido-1-hexanamine; 6-azidohexylamine; 6-Azido-1-hexaneamine
IUPAC Name
6-azidohexan-1-amine
Canonical SMILES
C(CCCN=[N+]=[N-])CCN
InChI
InChI=1S/C6H14N4/c7-5-3-1-2-4-6-9-10-8/h1-7H2
InChIKey
CLQMAUAPICAWGT-UHFFFAOYSA-N
Pictograms
Flammable; Corrosive
Signal Word
Danger

6-Azido-hexylamine, a versatile chemical compound, plays a pivotal role in bioconjugation, molecular biology, and materials science. Here are four key applications of 6-Azido-hexylamine presented with a high degree of perplexity and burstiness:

Bioconjugation: Serving as a linchpin in click chemistry, 6-Azido-hexylamine is a go-to compound for bioconjugation of biomolecules. Its azide group selectively reacts with alkynes in a copper-catalyzed dance, paving the way for attaching diverse probes, drugs, or fluorophores to proteins, nucleic acids, or other biomolecules. This intricate process allows for the precise tracking, imaging, and functionalization of biological targets, opening new vistas for intricate molecular manipulations.

Drug Delivery: In the realm of drug delivery research, 6-Azido-hexylamine emerges as a stalwart, aiding in the modification of drug carriers such as liposomes, nanoparticles, and polymers. By forming a stable azide-alkyne union, therapeutic molecules can be securely tethered to these carriers, ensuring controlled and targeted drug release mechanisms. This strategic maneuver not only enhances treatment efficacy and safety by guiding drugs to specific cells or tissues but also underscores the finesse involved in pharmaceutical interventions.

Materials Science: Unleashing its prowess in materials science, 6-Azido-hexylamine assumes a central role in surface functionalization and material development with tailored properties. By wielding its transformative touch on nanoparticle surfaces, this compound engineers materials boasting bespoke chemical and physical characteristics. This artistry finds resonance in the creation of advanced materials catering to diverse applications in catalysis, sensor technologies, and nano-engineering, marking a renaissance in material innovations.

Molecular Biology: In the intricate realm of molecular biology, 6-Azido-hexylamine emerges as a beacon, particularly in crafting labeled DNA and RNA probes. By incorporating the azido group into nucleic acid sequences, it lays the groundwork for attaching fluorescent dyes or other detection molecules through the elegant choreography of click chemistry. This synergy is indispensable for a myriad of assays, including the intricate dance of fluorescence in situ hybridization (FISH) and other nucleic acid-based detection methodologies, painting a vivid canvas of molecular intricacies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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