Name: DOTA-NHS-ester TFA Salt
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

DOTA-NHS-ester (trifluoroacetic acid salt); 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid mono(N-hydroxysuccinimidyl) ester TFA Salt; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(N-hydroxysuccinimide ester) TFA Salt; 2,2',2''-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid 2,2,2-trifluoroacetic acid; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester, 2,2,2-trifluoroacetate (1:4)

IUPAC Name

2-[4,10-bis(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid;2,2,2-trifluoroacetic acid

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CN2CCN(CCN(CCN(CC2)CC(=O)O)CC(=O)O)CC(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

InChI

InChI=1S/C20H31N5O10.4C2HF3O2/c26-15-1-2-16(27)25(15)35-20(34)14-24-9-7-22(12-18(30)31)5-3-21(11-17(28)29)4-6-23(8-10-24)13-19(32)33;4*3-2(4,5)1(6)7/h1-14H2,(H,28,29)(H,30,31)(H,32,33);4*(H,6,7)

InChIKey

WVLJPWRAOMGIOF-UHFFFAOYSA-N

DOTA-NHS-ester TFA Salt, a versatile chelating agent in bioconjugation and molecular imaging, finds diverse applications in the following realms:

Radioisotope Labeling: Widely utilized for radiopharmaceutical development, DOTA-NHS-ester TFA Salt acts as a key component in conjugating biomolecules with radioisotopes for both diagnostic imaging and therapeutic interventions. By coupling radioactive metals to peptides or antibodies, scientists craft imaging agents for PET and SPECT scans, enabling visual tracking of drug distribution in the body and facilitating disease diagnosis and treatment monitoring.

Targeted Drug Delivery: In the specialized field of targeted drug delivery, DOTA-NHS-ester TFA Salt plays a pivotal role in labeling therapeutic agents for precise localization within the body. Through conjugation with drugs or nanoparticles, researchers can guide drug carriers to specific tissues or tumor sites, enhancing treatment efficacy while minimizing off-target effects. This strategic delivery mechanism ensures that medications reach their intended destinations with pinpoint accuracy.

MRI Contrast Agents: Enabling the development of contrast agents for magnetic resonance imaging, DOTA-NHS-ester TFA Salt, when chelated with gadolinium, enhances MRI scan contrast, leading to improved visualization of anatomical structures and pathological features. This application proves invaluable for early detection and characterization of tumors and various medical conditions, heightening diagnostic precision and aiding in informed clinical decisions.

Bioconjugation Research: Within the realm of bioconjugation studies, DOTA-NHS-ester TFA Salt serves as an indispensable tool for linking biomolecules together, allowing researchers to create novel biomaterials and explore molecular interactions. By facilitating the attachment of proteins, peptides, or molecules to surfaces, this compound fuels the development of biosensors, immunoassays, and other biotechnological innovations, expanding the frontier of bioconjugation research and its potential applications in various scientific domains.