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DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET, SPECT, and CT.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00987 | -- | $-- | Inquiry |
DOTA-NHS-ester, a versatile bifunctional chelating agent, finds widespread use in the biosciences, particularly in imaging and therapeutic realms. Explore its key applications:
Radioisotope Labeling: Delving into diagnostic imaging, DOTA-NHS-ester plays a pivotal role in creating radio-labeled biomolecules. By linking it to proteins, peptides, or antibodies, researchers can effectively bind metal radioisotopes for PET and SPECT imaging. This method enables precise localization and imaging of tumors, inflammation, or other pathological conditions in clinical diagnostics.
Theranostics: In the dynamic field of theranostics, DOTA-NHS-ester serves as a crucial component in generating conjugates that can both diagnose and treat diseases. Through its attachment to therapeutic molecules and labeling with therapeutic radioisotopes, targeted radionuclide therapy becomes a reality. This dual-action capability allows for real-time monitoring and treatment of diseases, significantly enhancing patient outcomes and treatment effectiveness.
Magnetic Resonance Imaging (MRI): Transcending conventional imaging techniques, DOTA-NHS-ester can be linked to gadolinium, a well-known MRI contrast agent, to elevate the quality of imaging results. By binding DOTA-NHS-ester to targeting molecules like cancer-specific peptides, more detailed and precise MRI scans can be achieved. This advanced imaging strategy is essential for accurate disease diagnosis and monitoring, pushing the boundaries of medical diagnostics.
Protein and Peptide Conjugation: Expanding its utility beyond imaging, DOTA-NHS-ester is instrumental in the conjugation of proteins and peptides for diverse research endeavors. This application facilitates the exploration of protein-protein interactions and aids in the delivery of therapeutic agents within cells, fostering advancements in drug development and various biomedical research initiatives.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
