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MC-betaglucuronide-MMAE-1

  CAS No.: 1703778-92-0   Cat No.: BADC-01459 4.5  

MC-betaglucuronide-MMAE-1 is part of an antibody-drug conjugate consisting of tubulin polymerization inhibitor MMAE and degradable ADC linker MC-betaglucuronide.

MC-betaglucuronide-MMAE-1

Structure of 1703778-92-0

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Category
ADC Cytotoxin
Molecular Formula
C66H98N8O20
Molecular Weight
1323.53

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
MC-betaglucuronide-MMAE-1
IUPAC Name
(2S,3S,4S,5R,6S)-6-[2-[3-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]propanoylamino]-4-[[[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-methylcarbamoyl]oxymethyl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
Canonical SMILES
CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)OCC3=CC(=C(C=C3)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)CCNC(=O)CCCCCN5C(=O)C=CC5=O
InChI
InChI=1S/C66H98N8O20/c1-13-38(6)54(46(90-11)34-51(79)73-32-20-23-44(73)59(91-12)39(7)61(84)68-40(8)55(80)42-21-16-14-17-22-42)71(9)63(86)52(36(2)3)70-62(85)53(37(4)5)72(10)66(89)92-35-41-25-26-45(93-65-58(83)56(81)57(82)60(94-65)64(87)88)43(33-41)69-48(76)29-30-67-47(75)24-18-15-19-31-74-49(77)27-28-50(74)78/h14,16-17,21-22,25-28,33,36-40,44,46,52-60,65,80-83H,13,15,18-20,23-24,29-32,34-35H2,1-12H3,(H,67,75)(H,68,84)(H,69,76)(H,70,85)(H,87,88)/t38-,39+,40+,44-,46+,52-,53-,54-,55+,56-,57-,58+,59+,60-,65+/m0/s1
InChIKey
SBQIJGOPQUXPJF-CDCONWBCSA-N

MC-betaglucuronide-MMAE-1, a cutting-edge targeted therapeutic agent tailored for precision oncology and diverse biomedical applications, boasts remarkable efficacy.

Cancer Therapy: Standing as a formidable anti-cancer powerhouse, MC-betaglucuronide-MMAE-1 operates through a precision-targeted delivery mechanism. This agent is intricately conjugated to an antibody engineered to home in on tumor-associated antigens, facilitating the precise transportation of the cytotoxic MMAE payload to malignant cells. By honing in on cancer cells with pinpoint accuracy, this targeted therapy not only minimizes collateral damage to healthy tissues but also amplifies the treatment's effectiveness across various cancer subtypes.

Antibody-Drug Conjugates (ADCs): Spearheading the realm of cancer therapeutics, MC-betaglucuronide-MMAE-1 takes center stage as a pivotal component in ADCs—a groundbreaking approach in cancer treatment. By integrating the glucuronide-MMAE conjugate with antibodies or peptides exhibiting high specificity towards cancer markers, these ADCs orchestrate the direct delivery of lethal toxins exclusively to cancerous cells.

Pharmacokinetic and Toxicity Studies: Driving forward preclinical and clinical investigations, MC-betaglucuronide-MMAE-1 serves as a cornerstone in evaluating drug metabolism, pharmacokinetics, and toxicity profiles within novel therapeutic paradigms. These meticulous studies play a pivotal role in determining optimal dosing strategies, unraveling potential side effects, and identifying toxicities that could emerge. A deep comprehension of these profiles is paramount for the secure and efficacious integration of this therapeutic agent into clinical environments, ensuring patient safety and treatment success.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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