Boc-Gly-Gly-Phe-Gly-OH (TFA) - CAS 2450273-39-7

Boc-Gly-Gly-Phe-Gly-OH (TFA) - CAS 2450273-39-7 Catalog number: BADC-01711

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Boc-Gly-Gly-Phe-Gly-OH TFA is a protease cleavable linker used for the antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Boc-Gly-Gly-Phe-Gly-OH (TFA)
CAS
2450273-39-7
Catalog Number
BADC-01711
Molecular Formula
C22H29F3N4O9
Molecular Weight
550.48

Ordering Information

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Related Molecules

Description
Boc-Gly-Gly-Phe-Gly-OH TFA is a protease cleavable linker used for the antibody-drug conjugates (ADCs).
Synonyms
(tert-Butoxycarbonyl)glycylglycyl-L-phenylalanylglycine 2,2,2-trifluoroacetic acid salt
IUPAC Name
2-[[(2S)-2-[[2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid;2,2,2-trifluoroacetic acid
Canonical SMILES
CC(C)(C)OC(=O)NCC(=O)NCC(=O)NC(CC1=CC=CC=C1)C(=O)NCC(=O)O.C(=O)(C(F)(F)F)O
InChI
InChI=1S/C20H28N4O7.C2HF3O2/c1-20(2,3)31-19(30)23-10-15(25)21-11-16(26)24-14(18(29)22-12-17(27)28)9-13-7-5-4-6-8-13;3-2(4,5)1(6)7/h4-8,14H,9-12H2,1-3H3,(H,21,25)(H,22,29)(H,23,30)(H,24,26)(H,27,28);(H,6,7)/t14-;/m0./s1
InChIKey
RXCXUMYQOKOAGZ-UQKRIMTDSA-N

Boc-Gly-Gly-Phe-Gly-OH (TFA) is a protected peptide widely utilized in bioscience research and pharmaceutical manufacturing. Here are four key applications of Boc-Gly-Gly-Phe-Gly-OH (TFA) presented with high perplexity and burstiness:

Peptide Synthesis: Acting as a crucial building block in peptide and protein synthesis, Boc-Gly-Gly-Phe-Gly-OH (TFA) plays a pivotal role. Its Boc protecting group enables selective reactions with other amino acids, preventing premature interactions. This mechanism facilitates the efficient assembly of peptides, ensuring high purity and yield levels.

Drug Development: Within the realm of pharmaceutical exploration, Boc-Gly-Gly-Phe-Gly-OH (TFA) contributes significantly to the creation of peptide-based drug candidates. Researchers leverage this peptide to investigate drug-receptor interactions and assess the therapeutic potential of novel medications. Its well-defined structure positions it as an ideal candidate for conducting structure-activity relationship studies in drug development.

Enzyme Substrate Studies: Frequently utilized as a substrate in enzymatic assays, Boc-Gly-Gly-Phe-Gly-OH (TFA) enables scientists to delve into the activities and specificities of proteolytic enzymes. Through monitoring how enzymes cleave this peptide, valuable insights into enzyme kinetics and mechanisms are garnered. This knowledge serves as a cornerstone for designing enzyme inhibitors and therapeutic interventions.

Structural Biology: In the domain of structural biology, Boc-Gly-Gly-Phe-Gly-OH (TFA) finds application in constructing peptide models for X-ray crystallography and NMR studies. These models aid scientists in deciphering the three-dimensional structures and folding mechanisms of proteins. Accurate structural data is indispensable for rational drug design and unraveling protein functionalities at a molecular level.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: FSP-1 | Boc-Gly-Gly-Phe-Gly-OH (TFA)
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