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Tolytoxin

  CAS No.: 127999-44-4   Cat No.: BADC-01437 4.5  

Tolytoxin, a bioactive metabolite from cyanobacteria, is a potent antifungal antibiotic, exhibiting MICs of 0.25-8 nmol. Tolytoxin is a cyanobacterial macrolide that targets actin by inhibition of its polymerization. Tolytoxin has cytotoxic effects in cancer cells.

Tolytoxin

Structure of 127999-44-4

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Category
ADC Cytotoxin
Molecular Formula
C21H23NO6
Molecular Weight
385.410
Shipping
-15°C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
2,7,10-Trioxa-4-azadodecan-12-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-; [2-[2-(Fmoc-Amino)ethoxy]ethoxy]acetic acid; [2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid; 8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid; {2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-acetic acid; Fmoc-NH-PEG2-CH2COOH; MFCD01321015; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid; [2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid; 2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid; 8-[(9H-Fluoren-9-ylMethoxy)carbonylaMino]-3,6-dioxa-n-octanoic Acid; Fmoc-mini-PEG; Fmoc-AEEA
IUPAC Name
N-[(E,3R,4R,5R,9S,10S,11S)-10-hydroxy-11-[(1S,3S,4S,5S,7R,8S,9R,12E,14E,16S,17R,19R)-16-hydroxy-3,5,7,17-tetramethoxy-8,14-dimethyl-11-oxospiro[10,23-dioxabicyclo[17.3.1]tricosa-12,14,20-triene-4,2'-oxirane]-9-yl]-4-methoxy-3,5,9-trimethyl-6-oxododec-1-enyl]-N-methylformamide
Canonical SMILES
CC1C(CC(C2(CO2)C(CC3CC=CC(O3)CC(C(C=C(C=CC(=O)OC1C(C)C(C(C)CCC(=O)C(C)C(C(C)C=CN(C)C=O)OC)O)C)O)OC)OC)OC)OC
InChI
InChI=1S/C46H75NO13/c1-28-16-19-42(51)60-45(33(6)43(52)29(2)17-18-36(49)31(4)44(57-12)30(3)20-21-47(7)27-48)32(5)38(53-8)25-41(56-11)46(26-58-46)40(55-10)24-35-15-13-14-34(59-35)23-39(54-9)37(50)22-28/h13-14,16,19-22,27,29-35,37-41,43-45,50,52H,15,17-18,23-26H2,1-12H3/b19-16+,21-20+,28-22+/t29-,30+,31-,32-,33-,34-,35-,37-,38+,39+,40-,41-,43-,44+,45-,46-/m0/s1
InChIKey
FTGOWEQDZZMPNJ-GUMZKTDUSA-N
Density
1.3±0.1 g/cm3
Melting Point
90-92°C
Flash Point
335.6±28.7 °C
Index Of Refraction
1.580
PSA
94.09000
Vapor Pressure
0.0±1.9 mmHg at 25°C
Storage
-15°C
Boiling Point
631.4±45.0 °C at 760 mmHg
In Vivo
Tolytoxin is highly toxic to mice, exhibiting an LD50 (ip) of 1.5 mg/kg.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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