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Fmoc-NH-PEG5-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01142 | -- | $-- | Inquiry |
Fmoc-N-amido-PEG5-acetic acid is a versatile compound widely used in peptide and bioconjugation chemistry. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the amino terminus, facilitating stepwise synthesis of peptides in solid-phase peptide synthesis (SPPS). This protection ensures controlled addition of amino acid residues and other functional moieties, making it a critical building block in the development of functionalized peptides and complex biomolecules.
A key feature of Fmoc-N-amido-PEG5-acetic acid is the incorporation of a polyethylene glycol (PEG) chain with five ethylene glycol units. The PEG5 moiety enhances the solubility and flexibility of the compound, which is particularly advantageous in bioconjugation. The PEG chain acts as a hydrophilic spacer, reducing steric hindrance and improving the bioavailability, stability, and pharmacokinetics of peptide-based drugs or conjugates. This functionality makes the compound essential for the synthesis of biocompatible and long-circulating therapeutic agents.
Fmoc-N-amido-PEG5-acetic acid is extensively used in the development of peptide-drug conjugates (PDCs) and antibody-drug conjugates (ADCs). The PEG5 spacer facilitates the precise attachment of cytotoxic agents, targeting ligands, or imaging probes to peptides or antibodies while maintaining their bioactivity. This tailored conjugation improves drug targeting to diseased tissues, such as tumors, while minimizing off-target effects, making it crucial for advanced drug delivery systems.
Another significant application of Fmoc-N-amido-PEG5-acetic acid is in the design of self-assembling peptides and hydrogels. The PEG chain enhances the hydrophilic properties of peptides, promoting the formation of stable nanostructures such as micelles, vesicles, or hydrogels. These structures have broad applications in drug delivery, regenerative medicine, and tissue engineering. The flexibility of the PEG5 linker allows researchers to fine-tune the physical and chemical properties of the resulting materials, optimizing their performance for specific biomedical applications.
Additionally, Fmoc-N-amido-PEG5-acetic acid is used in surface modification and biomaterials engineering. It enables the attachment of peptides or other bioactive molecules to surfaces, such as nanoparticles, hydrogels, or biosensors, to improve biocompatibility and functionalization. This capability is highly valuable in creating targeted delivery systems, diagnostic tools, and biosensing devices, ensuring precise interactions with biological environments.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
