Inquiry Basket
Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01175 | -- | $-- | Inquiry |
Fmoc-N-amido-PEG8-acetic acid, a versatile linker prevalent in peptide and protein chemistry, showcases a multitude of applications across various fields. Here are four key applications of this compound:
Peptide Synthesis: Positioned at the heart of solid-phase peptide synthesis (SPPS), Fmoc-N-amido-PEG8-acetic acid stands as a crucial instrument for constructing elaborate and extended peptides. The incorporation of a polyethylene glycol (PEG) spacer not only boosts solubility but also mitigates aggregation, streamlining the synthesis and purification processes. Researchers harness this linker to fabricate peptides tailored for drug development, molecular biology inquiries, and therapeutic endeavors.
Protein Conjugation: Acting as a cornerstone in protein conjugation, this compound facilitates the coupling of proteins with an array of biomolecules spanning from drugs to fluorophores to other peptides. Serving as a flexible and hydrophilic bridge, the linker preserves the biological functionality of proteins while enhancing their solubility and stability. This capability proves pivotal in fabricating bioconjugates for targeted drug delivery systems and diagnostic applications.
Drug Delivery Systems: Standing at the forefront of drug delivery innovation, Fmoc-N-amido-PEG8-acetic acid plays a pivotal role in crafting cutting-edge drug delivery platforms, including nanoparticle and liposome formulations. Through the process of PEGylation, the pharmacokinetic properties are bolstered while reducing the immunogenicity of delivery systems. By affixing this linker to therapeutic agents, researchers can precisely modulate drug release profiles, amplifying treatment efficacy and reinforcing patient adherence.
Surface Functionalization: Within the realm of surface chemistry, this linker emerges as a key protagonist in functionalizing biomaterial surfaces to augment biocompatibility and anti-fouling attributes. PEGylation of surfaces, such as implants or biosensors, diminishes protein adsorption and cell adhesion, thereby enhancing device functionality and durability. This advancement elevates the utility of biotechnological devices in medical and analytical settings, underscoring the significance of surface modification in optimizing device performance and longevity with intricate precision.
Customer Support
Providing excellent 24/7 customer service and support
Project Management
Offering 100% high-quality services at all stages
Quality Assurance
Ensuring the quality and reliability of products or services
Global Delivery
Ensuring timely delivery of products worldwide
BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
