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Propargyl-PEG2-amine

  CAS No.: 944561-44-8   Cat No.: BADC-01196   Purity: ≥ 95.0 % 4.5  

Propargyl-PEG2-amine is a small alkyne-functionalized linker used for copper-catalyzed click reactions in ADC construction. It provides a flexible and hydrophilic spacer for site-specific antibody labeling, supporting diverse bioconjugation workflows.

Propargyl-PEG2-amine

Structure of 944561-44-8

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Category
ADC Linker
Molecular Formula
C7H13NO2
Molecular Weight
143.18
Shipping
Room temperature, or blue ice upon request.
Shipping
Store at -20 °C, keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
Alkyne-PEG2-Amine;2-[2-(2-Propynyloxy)ethoxy]ethylamine; Propyne-PEG2-NH2; 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
IUPAC Name
2-(2-prop-2-ynoxyethoxy)ethanamine
Canonical SMILES
C#CCOCCOCCN
InChI
InChI=1S/C7H13NO2/c1-2-4-9-6-7-10-5-3-8/h1H,3-8H2
InChIKey
GVHLQHHQXWSDDM-UHFFFAOYSA-N
Density
1.0±0.1 g/cm3
Solubility
10 mm in DMSO
PSA
44.48000
Appearance
Colorless to almost colorless clear liquid
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Pictograms
Corrosive; Irritant
Signal Word
Danger
Boiling Point
213.8±20.0 °C at 760 mmHg
Biological Activity
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2- amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: Me-Tet-PEG4-COOH | Cyclooctyne-O-amido-PEG4-NHS ester | Propargyl-PEG5-amine | ethyl azetidine-3-carboxylate hydrochloride | Propargyl-PEG2-amine
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