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Fmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00895 | -- | $-- | Inquiry |
Fmoc-N-amido-PEG9-acid, a versatile compound widely applied in peptide synthesis and biomedical research, presents a spectrum of pivotal functions.
Peptide Synthesis: Serving as a fundamental component in solid-phase peptide synthesis, Fmoc-N-amido-PEG9-acid plays a crucial role in constructing peptides. Acting as a spacer, it enhances the solubility and flexibility of resulting peptides, particularly those of intricate nature, utilized in therapeutic and diagnostic realms. The compound enables the efficient and dependable synthesis of complex peptides.
Drug Delivery: Embracing innovation in drug delivery systems, Fmoc-N-amido-PEG9-acid is instrumental in designing novel approaches. The incorporation of the PEG moiety elevates the solubility and stability of drug molecules, bolstering their bioavailability and circulation time within the body. This characteristic is particularly advantageous for formulating peptide and protein drugs that necessitate prolonged systemic exposure.
Surface Modification: Extending its reach to surface functionalization, Fmoc-N-amido-PEG9-acid is harnessed for modifying diverse surfaces, including nanoparticles, biomaterials, and medical devices. By tethering PEG chains to these surfaces, the compound mitigates protein adsorption and cell adhesion, thereby amplifying biocompatibility. This technique of surface modification is vital for crafting therapeutics and implants that minimize immune reactions, leading to enhanced patient outcomes and improved clinical efficacy.
Bioconjugation: Playing a pivotal role in bioconjugation strategies, Fmoc-N-amido-PEG9-acid facilitates the linkage of biomolecules like antibodies, enzymes, and nucleic acids to synthetic carriers or other biomolecules. The PEG linker ensures that the conjugated molecules retain their biological activity and functionality, thereby enabling the development of targeted therapies, diagnostic assays, and biosensors.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
