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Fmoc-NH-PEG8-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01153 | -- | $-- | Inquiry |
Fmoc-N-amido-PEG8-propionic acid, a versatile reagent widely employed in peptide chemistry and drug development, boasts diverse applications. Here are four key applications of Fmoc-N-amido-PEG8-propionic acid:
Peptide Synthesis: Serving as a critical component in solid-phase peptide synthesis, Fmoc-N-amido-PEG8-propionic acid functions as a vital linker. It streamlines the attachment of polyethylene glycol (PEG) chains to peptides, enhancing solubility and mitigating aggregation concerns. This modification proves especially valuable for synthesizing lengthy or hydrophobic peptides.
Drug Conjugation: In the realm of drug development, Fmoc-N-amido-PEG8-propionic acid plays a pivotal role in conjugating drugs to targeted delivery systems. PEGylation facilitated by this reagent bolsters drug stability and extends its half-life in the bloodstream, while concurrently reducing immunogenicity.
Protein Modification: Unlocking a spectrum of biomedical applications, Fmoc-N-amido-PEG8-propionic acid enables the modification of proteins for diverse purposes. By affixing PEG chains to proteins, researchers elevate protein solubility and stability, augmenting their therapeutic efficacy.
Surface Functionalization: Delving into the realm of biosensing and bioengineering, Fmoc-N-amido-PEG8-propionic acid emerges as a linchpin for surface functionalization. Leveraging PEGylation, surfaces can be shielded against nonspecific protein adsorption, fostering enhanced biocompatibility. This process stands as a linchpin for crafting robust and sensitive biosensors, as well as engineering biomaterials essential for medical devices, illuminating the pivotal role this reagent plays in driving innovation in bioscience.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
