Name: Fmoc-N-amido-PEG8-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

Fmoc-N-amido-PEG8-acid; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid; Fmoc-NH-PEG8-CH2CH2COOH; 1-(Fmoc-amino)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic Acid; Fmoc-PEG8-propionic acid; 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(9-fluren-9-ylmethyl)ester; 2,7,10,13,16,19,22,25,28-Nonaoxa-4-azahentriacontan-31-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-

IUPAC Name

3-[2-[2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Canonical SMILES

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

InChI

InChI=1S/C34H49NO12/c36-33(37)9-11-39-13-15-41-17-19-43-21-23-45-25-26-46-24-22-44-20-18-42-16-14-40-12-10-35-34(38)47-27-32-30-7-3-1-5-28(30)29-6-2-4-8-31(29)32/h1-8,32H,9-27H2,(H,35,38)(H,36,37)

InChIKey

VYXGUCLTEWCVRY-UHFFFAOYSA-N

Density

1.190±0.06 g/cm3

Solubility

Soluble in DMSO (10 mm)

PSA

149.47000

Appearance

Colourless to pale yellow liquid

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20°C, keep in dry and avoid sunlight

Boiling Point

781.1±60.0 °C at 760 mmHg

Form

Liquid

Fmoc-N-amido-PEG8-propionic acid, a versatile reagent widely employed in peptide chemistry and drug development, boasts diverse applications. Here are four key applications of Fmoc-N-amido-PEG8-propionic acid:

Peptide Synthesis: Serving as a critical component in solid-phase peptide synthesis, Fmoc-N-amido-PEG8-propionic acid functions as a vital linker. It streamlines the attachment of polyethylene glycol (PEG) chains to peptides, enhancing solubility and mitigating aggregation concerns. This modification proves especially valuable for synthesizing lengthy or hydrophobic peptides.

Drug Conjugation: In the realm of drug development, Fmoc-N-amido-PEG8-propionic acid plays a pivotal role in conjugating drugs to targeted delivery systems. PEGylation facilitated by this reagent bolsters drug stability and extends its half-life in the bloodstream, while concurrently reducing immunogenicity.

Protein Modification: Unlocking a spectrum of biomedical applications, Fmoc-N-amido-PEG8-propionic acid enables the modification of proteins for diverse purposes. By affixing PEG chains to proteins, researchers elevate protein solubility and stability, augmenting their therapeutic efficacy.

Surface Functionalization: Delving into the realm of biosensing and bioengineering, Fmoc-N-amido-PEG8-propionic acid emerges as a linchpin for surface functionalization. Leveraging PEGylation, surfaces can be shielded against nonspecific protein adsorption, fostering enhanced biocompatibility. This process stands as a linchpin for crafting robust and sensitive biosensors, as well as engineering biomaterials essential for medical devices, illuminating the pivotal role this reagent plays in driving innovation in bioscience.

Catalog	Product Name	CAS
BADC-01135	Fmoc-N-amido-PEG4-propionic acid	557756-85-1
BADC-01171	Fmoc-N-amido-PEG3-propionic acid	867062-95-1
BADC-01179	Fmoc-N-amido-PEG2-propionic acid	872679-70-4
BADC-01185	Fmoc-N-amido-PEG6-propionic acid	882847-34-9