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Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01171 | -- | $-- | Inquiry |
Fmoc-N-amido-PEG3-propionic acid, a versatile compound essential in peptide synthesis and drug development, finds diverse applications across various fields.
Peptide Synthesis: Within the realm of peptide chemistry, Fmoc-N-amido-PEG3-propionic acid plays a pivotal role as a linker, facilitating the attachment of polyethylene glycol (PEG) to peptides, thereby enhancing their solubility and stability. This spacer unit effectively mitigates steric hindrance during consecutive amino acid coupling, making it a favored choice for synthesizing intricate peptides, particularly those earmarked for therapeutic endeavors.
Drug Delivery: In the domain of drug development, Fmoc-N-amido-PEG3-propionic acid emerges as a critical component in designing drug delivery systems geared towards optimizing the pharmacokinetic properties of therapeutic agents. By conjugating drugs to PEG chains via this compound, it enhances drug solubility while diminishing immunogenicity. This strategic approach is imperative for creating long-circulating drugs that exhibit heightened efficacy and reduced toxicity.
Bioconjugation: Firmly entrenched in bioconjugation strategies, this compound acts as a linchpin in linking biomolecules, such as proteins and antibodies, to PEG chains or other functional groups, bolstering the stability and bioavailability of biotherapeutics. Employing Fmoc-N-amido-PEG3-propionic acid for bioconjugation not only opens avenues for innovative diagnostic tools and targeted therapies but also underscores its pivotal role in advancing bioconjugation as a fundamental pillar of modern biotechnology.
Surface Modification: Delving into surface modification applications, Fmoc-N-amido-PEG3-propionic acid emerges as a versatile tool for enhancing biocompatibility and curbing non-specific binding on biomaterial surfaces. Encasing medical devices or biosensors with PEGylated layers via this compound can effectively ward off protein adsorption and cellular adhesion, presenting a boon for implants, stents, and other devices necessitating prolonged contact with biological fluids. This surface modification strategy stands as a testament to the compound’s multifaceted utility in the field of biomaterials engineering.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
