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Fmoc-N-amido-PEG3-propionic acid

  CAS No.: 867062-95-1   Cat No.: BADC-01171   Purity: ≥95% 4.5  

Fmoc-N-amido-PEG3-propionic acid offers an optimized PEG3 spacer with Fmoc protection, facilitating enhanced conjugation specificity and improved solubility. It is ideal for ADC development requiring precise linker functionality and stability.

Fmoc-N-amido-PEG3-propionic acid

Structure of 867062-95-1

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Category
ADC Linker
Molecular Formula
C24H29NO7
Molecular Weight
443.49
Shipping
-20°C (International: -20°C)
Shipping
Store at 2-8°C under inert atmosphere

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid; Fmoc-N-amido-PEG3-acid; Fmoc-NH-PEG3-CH2CH2COOH; Fmoc-PEG3-propionic acid; 12-(Fmoc-amino)-4,7,10-trioxadodecanoic Acid; 5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester; N-Fmoc-12-amino-4,7,10-trioxadodecanoic acid; 12-[(9H-Fluorene-9-yl)methoxycarbonylamino]-4,7,10-trioxadodecanoic acid; N-Fmoc-12-amino-4,7,10-trioxadodecanoic acid
IUPAC Name
3-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCC(=O)O
InChI
InChI=1S/C24H29NO7/c26-23(27)9-11-29-13-15-31-16-14-30-12-10-25-24(28)32-17-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-8,22H,9-17H2,(H,25,28)(H,26,27)
InChIKey
CHIDDYZONKDHLG-UHFFFAOYSA-N
Density
1.230±0.06 g/cm3 (Predicted)
Solubility
Soluble in DMSO (Sparingly), Methanol (Slightly)
Melting Point
43-46°C
Flash Point
348.0±31.5 °C
Index Of Refraction
1.562
PSA
103.32000
Vapor Pressure
0.0±2.1 mmHg at 25°C
Appearance
Pale Yellow or Colorless Oily Matter
Shipping
-20°C (International: -20°C)
Storage
Store at 2-8°C under inert atmosphere
Boiling Point
651.9±55.0 °C at 760 mmHg
Form
Solid
Biological Activity
Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Fmoc-N-amido-PEG3-propionic acid, a versatile compound essential in peptide synthesis and drug development, finds diverse applications across various fields.

Peptide Synthesis: Within the realm of peptide chemistry, Fmoc-N-amido-PEG3-propionic acid plays a pivotal role as a linker, facilitating the attachment of polyethylene glycol (PEG) to peptides, thereby enhancing their solubility and stability. This spacer unit effectively mitigates steric hindrance during consecutive amino acid coupling, making it a favored choice for synthesizing intricate peptides, particularly those earmarked for therapeutic endeavors.

Drug Delivery: In the domain of drug development, Fmoc-N-amido-PEG3-propionic acid emerges as a critical component in designing drug delivery systems geared towards optimizing the pharmacokinetic properties of therapeutic agents. By conjugating drugs to PEG chains via this compound, it enhances drug solubility while diminishing immunogenicity. This strategic approach is imperative for creating long-circulating drugs that exhibit heightened efficacy and reduced toxicity.

Bioconjugation: Firmly entrenched in bioconjugation strategies, this compound acts as a linchpin in linking biomolecules, such as proteins and antibodies, to PEG chains or other functional groups, bolstering the stability and bioavailability of biotherapeutics. Employing Fmoc-N-amido-PEG3-propionic acid for bioconjugation not only opens avenues for innovative diagnostic tools and targeted therapies but also underscores its pivotal role in advancing bioconjugation as a fundamental pillar of modern biotechnology.

Surface Modification: Delving into surface modification applications, Fmoc-N-amido-PEG3-propionic acid emerges as a versatile tool for enhancing biocompatibility and curbing non-specific binding on biomaterial surfaces. Encasing medical devices or biosensors with PEGylated layers via this compound can effectively ward off protein adsorption and cellular adhesion, presenting a boon for implants, stents, and other devices necessitating prolonged contact with biological fluids. This surface modification strategy stands as a testament to the compound’s multifaceted utility in the field of biomaterials engineering.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: DC-1 | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate | (2,5-dioxopyrrolidin-1-yl) 4-(methyldisulfanyl)pentanoate | (2,5-dioxopyrrolidin-1-yl) 4-methyl-4-(methyldisulfanyl)pentanoate | (2,5-dioxopyrrolidin-1-yl) 4-(methyldisulfanyl)butanoate | Biotin-PEG4-PFP ester | Zilovertamab vedotin | CL2A-Chimmitecan | Fmoc-N-amido-PEG2-propionic acid | MC-VC-PABC-MMAE | Fmoc-N-amido-PEG3-propionic acid
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