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Pyridin-2-yldisulfanyl-PEG4-NHS

  CAS No.: 1305053-43-3   Cat No.: BADC-00460   Purity: ≥98% 4.5  

Pyridin-2-yldisulfanyl-PEG4-NHS is a heterobifunctional ADC linker designed for PEGylated, cleavable drug conjugation. The PEG4 spacer improves solubility and flexibility, while the NHS ester and pyridyl disulfide allow for site-specific thiol-reactive coupling in ADC and bioconjugate synthesis.

Pyridin-2-yldisulfanyl-PEG4-NHS

Structure of 1305053-43-3

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Category
ADC Linker
Molecular Formula
C20H28N2O8S2
Molecular Weight
488.57
Shipping
Room temperature
Shipping
Store at 2-8°C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
PEG4-SPDP; 15-(2-pyridyldithio)-4,7,10,13-tetraoxapentadecanoic acid N-hydroxysuccinimide ester; (2-pyridyldithio)-PEG4-NHS ester; 2,5-dioxopyrrolidin-1-yl 1-(pyridin-2-yldisulfaneyl)-3,6,9,12-tetraoxapentadecan-15-oate; 2,5-dioxo-1-pyrrolidinyl 15-(2-Pyridinyldithio)-4,7,10,13-tetraoxapentadecanoate; 1-{[15-(2-Pyridinyldisulfanyl)-4,7,10,13-tetraoxapentadecan-1-oyl]oxy}-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[[1-oxo-15-(2-pyridinyldithio)-4,7,10,13-tetraoxapentadec-1-yl]oxy]-; 4,7,10,13-Tetraoxapentadecanoic acid, 15-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCSSC2=CC=CC=N2
InChI
InChI=1S/C20H28N2O8S2/c23-18-4-5-19(24)22(18)30-20(25)6-8-26-9-10-27-11-12-28-13-14-29-15-16-31-32-17-3-1-2-7-21-17/h1-3,7H,4-6,8-16H2
InChIKey
AZXJOPLHLVNPKQ-UHFFFAOYSA-N
Density
1.3±0.1 g/cm3
Solubility
Soluble in DMSO
Appearance
Colorless to Light Yellow Viscous Liquid
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
605.9±65.0°C at 760 mmHg

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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