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Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01112 | -- | $-- | Inquiry |
Fmoc-N-amido-PEG1-acetic acid, a versatile chemical linker, finds wide utilization in biochemical and pharmaceutical research. Below are four key applications of this compound:
Peptide Synthesis: Integral to solid-phase peptide synthesis, Fmoc-N-amido-PEG1-acetic acid plays a crucial role in constructing peptides. The Fmoc group shields the terminal amino group throughout the synthesis process, enabling the sequential addition of amino acids. This method offers researchers a dependable approach to creating intricate peptides with elevated yields and purity levels.
Drug Delivery: This compound serves as a cornerstone in designing drug delivery systems that leverage PEG to enhance drug solubility, stability, and biocompatibility. By conjugating drugs to Fmoc-N-amido-PEG1-acetic acid, researchers can enhance the pharmacokinetic properties of the resulting compounds. This augmentation not only boosts therapeutic efficacy but also mitigates the adverse effects associated with drug treatments.
Surface Modification: Employing Fmoc-N-amido-PEG1-acetic acid enhances the biocompatibility and functionality of nanoparticle surfaces, biomaterials, and medical devices. The PEG component forms a hydrophilic layer that reduces protein adsorption and cellular interactions, crucial for applications spanning biosensors to implantable devices. This modification guarantees the stability and optimal performance of these devices within biological settings.
Protein Engineering: In the realm of protein engineering, Fmoc-N-amido-PEG1-acetic acid enables site-specific PEGylation of proteins, enhancing their pharmacokinetic characteristics. By attaching PEG chains to precise residues, researchers can prolong the circulation time of therapeutic proteins in the bloodstream while lowering their immunogenicity. This transformation renders the proteins more suitable for diverse therapeutic applications, promising advancements in the realm of medical treatments.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
