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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01178 | -- | $-- | Inquiry |
Boc-Val-Cit-OH, also known as N-tert-butoxycarbonyl-L-valyl-L-citrulline, is a chemical compound prominently used in biochemical research and drug development. This compound features a tert-butoxycarbonyl (Boc) protective group, which is critical for peptide synthesis as it prevents side reactions during the construction of peptide chains. Boc-Val-Cit-OH is particularly valued for its role in the synthesis of protease substrates and inhibitors, primarily within the pharmaceutical sector. Due to its stability and ease of removal, the Boc group is frequently employed to protect amino acids during peptide coupling reactions. This preservation allows researchers to manipulate and study the sequences of amino acids accurately without interference, making Boc-Val-Cit-OH a staple reagent for chemists and biochemists pursuing advanced drug formulations and therapeutic discoveries.
One of the key applications of Boc-Val-Cit-OH lies in the design of prodrugs, especially within cancer therapy. Prodrugs are inactive compounds that can be converted into active drugs upon exposure to specific conditions in the body. Boc-Val-Cit-OH is often integrated into drug-linker systems used in antibody-drug conjugates (ADCs). In this application, the compound serves as a cleavable linker that is stable in the bloodstream but undergoes cleavage due to enzymatic action in the tumor microenvironment. This selective activation is crucial, as it allows the cytotoxic drugs to target and destroy cancer cells while minimizing damage to healthy tissues, significantly enhancing the therapeutic index of the treatment. Consequently, the use of Boc-Val-Cit-OH in ADCs exemplifies a strategic advancement in precision oncology, offering potential breakthroughs in treating various cancers with increased efficacy and reduced side effects.
Furthermore, Boc-Val-Cit-OH is utilized in the development of controlled release systems for drugs. The ability to manipulate its chemical structure allows developers to design systems wherein the drug is released in specific environments or over a timed period. This technology is particularly invaluable in chronic disease management, where maintaining consistent drug levels in the system can improve treatment efficacy and patient compliance. By varying the linkers and modifying the Boc group in the compound, researchers can fine-tune the degradation process, optimizing it for a broad spectrum of therapeutic requirements. This adaptability not only enhances the precision of drug delivery systems but also significantly expands the potential applications of Boc-Val-Cit-OH beyond oncology, into other areas such as immunology, infectious diseases, and metabolic disorders.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
