Name: mPEG6-CH2CH2COONHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

COCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

InChI

InChI=1S/C20H35NO11/c1-25-6-7-27-10-11-29-14-15-31-17-16-30-13-12-28-9-8-26-5-4-20(24)32-21-18(22)2-3-19(21)23/h2-17H2,1H3

InChIKey

WFZQJHMGKLLCOJ-UHFFFAOYSA-N

Density

1.2±0.1 g/cm3

Appearance

Colorless Liquid

Shipping

Room temperature

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Boiling Point

535.8±60.0 °C at 760 mmHg

mPEG6-CH2CH2COONHS ester, a versatile compound extensively utilized in bioconjugation processes, facilitates the attachment of polyethylene glycol (PEG) to biomolecules. Here are four key applications of mPEG6-CH2CH2COONHS ester:

Protein Modification: Found commonly in protein modification, mPEG6-CH2CH2COONHS ester elevates proteins' solubility, stability, and therapeutic efficacy. By covalently linking PEG to proteins, researchers can elongate their half-life and mitigate immune responses in the body. This process, known as PEGylation, plays a pivotal role in advancing biopharmaceuticals with enhanced pharmacokinetic profiles.

Drug Delivery Systems: In the domain of developing drug delivery systems, mPEG6-CH2CH2COONHS ester assumes a crucial role in crafting pegylated liposomes and nanoparticles. PEGylation of drug carriers assists in evading the immune system and prolonging circulation time in the bloodstream. This leads to superior drug targeting in specific tissues, amplifying therapeutic outcomes while minimizing adverse effects.

Surface Modification: Applied in the alteration of implant surfaces, sensors, and other biomedical devices, mPEG6-CH2CH2COONHS ester metamorphoses surfaces into biocompatible entities resistant to protein adsorption and cell attachment. This modification prevents fouling and upholds the functional integrity of medical devices in vivo, ensuring optimal performance and longevity.

Diagnostic Assays: In the realm of diagnostics, mPEG6-CH2CH2COONHS ester plays a pivotal role in linking PEG to antibodies and other molecules for assay kit development. PEGylation enhances the solubility and stability of these molecules, resulting in more precise and sensitive diagnostic assays. This technique is indispensable in creating diagnostic tools for detecting various biomolecules in clinical and research settings.