Name: mPEG7-CH2CH2COONHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

2,5-DIOXOPYRROLIDIN-1-YL 2,5,8,11,14,17,20,23-OCTAOXAHEXACOSAN-26-OATE; MeO-dPEG(8)-NHS; (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate; mPEG7-NHS ester; m-dPEG(R)8-NHS ester; mPEG7-CH2CH2COONHS; 4,7,10,13,16,19,22,25-Octaoxahexacosanoic acid 2,5-dioxo-1-pyrrolidinyl ester; N-Succinimidyl 4,7,10,13,16,19,22,25-Octaoxahexacosanoate; 2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid succinimidyl ester; 4,7,10,13,16,19,22,25-Octaoxahexacosanoic Acid N-Succinimidyl Ester; 1-[(26-Oxo-2,5,8,11,14,17,20,23-octaoxahexacosan-26-yl)oxy]pyrrolidine-2,5-dione

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O

InChI

InChI=1S/C22H39NO12/c1-27-6-7-29-10-11-31-14-15-33-18-19-34-17-16-32-13-12-30-9-8-28-5-4-22(26)35-23-20(24)2-3-21(23)25/h2-19H2,1H3

InChIKey

IBZNTYBFTKFSMU-UHFFFAOYSA-N

Density

1.2±0.1 g/cm3

Solubility

10 mm in DMSO

PSA

137.52000

Appearance

Colorless to yellow clear liquid

Shelf Life

≥ 2 years

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Boiling Point

567.6±60.0 °C at 760 mmHg

Form

Liquid

mPEG7-CH2CH2COONHS ester, a derivative of polyethylene glycol (PEG), plays a crucial role in various bioconjugation processes. Here are four key applications of mPEG7-CH2CH2COONHS ester:

Protein Modification: Widely utilized for pegylating proteins, mPEG7-CH2CH2COONHS ester enhances solubility and stability while mitigating immunogenicity and proteolytic degradation. By appending PEG chains to therapeutic proteins, researchers can prolong their half-life in circulation, resulting in enhanced efficacy and patient adherence. This modification is pivotal in the development of durable biopharmaceuticals that revolutionize the treatment landscape.

Surface Functionalization: Embracing mPEG7-CH2CH2COONHS ester for surface modification of biomaterials and nanoparticles enhances biocompatibility and surface characteristics. PEGylation of surfaces diminishes protein adsorption and cell adhesion, making it suitable for medical devices and drug delivery systems.

Drug Delivery Systems: Integral in formulating drug delivery systems, this ester facilitates the conjugation of drugs to carrier molecules, optimizing pharmacokinetics and biodistribution for superior therapeutic outcomes. By tethering drugs to PEG chains, controlled release and targeted delivery of pharmaceuticals are enhanced, improving treatment precision and efficacy.

Diagnostic Assays: Leveraging mPEG7-CH2CH2COONHS ester to modify biomolecules in diagnostic assays boosts assay sensitivity and stability. By attaching PEG chains to antibodies or antigens, the binding properties and solubility of these biomolecules are fine-tuned, optimizing diagnostic accuracy. This critical step is pivotal in developing robust and sensitive diagnostic tools that drive advancements in medical and research settings.