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Fmoc-Gly3-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00710 | -- | $-- | Inquiry |
Fmoc-Gly3-Val-Cit-PAB, a cutting-edge linker prominently utilized in the development of antibody-drug conjugates (ADCs) and various targeted therapeutic agents, encompasses a multitude of applications. Here are four key applications of Fmoc-Gly3-Val-Cit-PAB eloquently:
Antibody-Drug Conjugates (ADCs): Positioned as a pivotal linkage component, Fmoc-Gly3-Val-Cit-PAB intricately bridges cytotoxic drugs to antibodies engineered for precise targeting of malignant cells. This linker orchestrates a sophisticated mechanism where the drug remains dormant during circulation, only springing into action upon encountering the designated cell. The selective activation paradigm not only curtails off-target toxicity but also amplifies the therapeutic index of the ADC.
Targeted Drug Delivery: The multifaceted nature of Fmoc-Gly3-Val-Cit-PAB facilitates the formulation of targeted drug delivery systems by linking therapeutic agents to molecules meticulously tailored to bind to disease-specific markers. This precision targeting strategy elevates drug efficacy while mitigating adverse effects by restricting payload release exclusively to the intended site of action.
Protease-Activated Prodrugs: Exploiting the inherent potential of Fmoc-Gly3-Val-Cit-PAB, researchers engineer prodrugs activated by proteases abundantly prevalent in diseased tissues. By leveraging the heightened enzymatic activity of specific proteases in conditions such as cancer and inflammatory diseases, this innovative approach enables targeted drug activation and release.
Biomedical Research: Positioned at the vanguard of preclinical explorations, Fmoc-Gly3-Val-Cit-PAB assumes a pivotal role in unraveling the intricacies of drug-linker stability, release kinetics, and targeting precision. Through meticulous examination of this linker’s performance in diverse experimental models, researchers refine the design intricacies of ADCs and targeted therapies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
