Maleimide-DOTA - CAS 1006711-90-5

Maleimide-DOTA - CAS 1006711-90-5 Catalog number: BADC-00874

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Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Maleimide-DOTA
CAS
1006711-90-5
Catalog Number
BADC-00874
Molecular Formula
C22H34N6O9
Molecular Weight
526.54
Maleimide-DOTA

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BADC-00874 -- $--
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Description
Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
DOTA-maleimido; Maleimide-monoamide-DOTA; Maleimido-mono-amide-DOTA; 1,4,7,10-tetraazacyclododecane-1,4,7-tris-acetic acid-10-maleimidoethylacetamide
IUPAC Name
2-[4,7-bis(carboxymethyl)-10-[2-[2-(2,5-dioxopyrrol-1-yl)ethylamino]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
Canonical SMILES
C1CN(CCN(CCN(CCN1CC(=O)NCCN2C(=O)C=CC2=O)CC(=O)O)CC(=O)O)CC(=O)O
InChI
InChI=1S/C22H34N6O9/c29-17(23-3-4-28-18(30)1-2-19(28)31)13-24-5-7-25(14-20(32)33)9-11-27(16-22(36)37)12-10-26(8-6-24)15-21(34)35/h1-2H,3-16H2,(H,23,29)(H,32,33)(H,34,35)(H,36,37)
InChIKey
AUTDIWAXETZSGJ-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Biological Activity
Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Purity
> 98%
Shelf Life
≥ 2 years
Shipping
Room temperature
Storage
-20 °C, protect from light.
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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