Inquiry Basket
CAS No.: 2101206-21-5
Cat No.: BADC-00639
4.5 
Ald-Ph-amido-PEG3-C2-Pfp ester is a PEGn linker for antibody-drug-conjugation (ADC). Ald-Ph-amido-PEG3-C2-Pfp ester is an noncleavable ADC linker, which belongs to a polyethylene glycol (PEG) linker.
Structure of 2101206-21-5
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
Popular Publications Citing BOC Sciences Products
Ald-Ph-amido-PEG3-C2-Pfp ester is a highly versatile ADC linker intermediate designed for antibody-drug conjugate (ADC) construction and targeted bioconjugation applications. Featuring an aldehyde functional group, a phenyl (Ph) amido spacer, a PEG3 chain, and a pentafluorophenyl (Pfp) ester, this linker enables efficient and site-specific conjugation with ADC cytotoxins and monoclonal antibodies. The PEG3 spacer provides hydrophilicity and flexibility, enhancing solubility and reducing steric hindrance, while the aldehyde and Pfp ester groups support dual conjugation strategies. In ADC linker design, this compound facilitates precise payload attachment while maintaining antibody functionality.
In payload conjugation applications, Ald-Ph-amido-PEG3-C2-Pfp ester is compatible with a wide range of ADC cytotoxins, including microtubule inhibitors, DNA-targeting agents, and other potent therapeutic molecules. The pentafluorophenyl ester enables selective, efficient, and reproducible conjugation to primary amines on antibodies, while the aldehyde functionality allows additional bioconjugation via oxime ligation. The PEG3 spacer enhances linker flexibility and solubility, supporting homogeneous and stable ADC construction. Researchers can employ this intermediate to optimize linker length, improve intracellular payload release, and construct high-performance ADCs suitable for both preclinical studies and industrial-scale production.
From an application perspective, Ald-Ph-amido-PEG3-C2-Pfp ester is widely applied in oncology-focused ADC research, protein bioconjugation studies, and advanced drug delivery systems. Its combination of hydrophilic PEG spacer, reactive aldehyde, and pentafluorophenyl ester enables predictable, flexible, and site-specific conjugation strategies while preserving antibody structure and activity. By integrating this intermediate into ADC linker design, developers can construct stable, efficient, and highly soluble linker-payload conjugates, supporting tumor-targeted delivery, optimized pharmacokinetics, and enhanced therapeutic performance in modern ADC development.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01028 | Ald-Ph-amido-PEG4-propargyl | 1969299-27-1 | |
| BADC-00652 | Ald-Ph-amido-PEG2-C2-Pfp ester | 2101206-60-2 | |
| BADC-00654 | Ald-Ph-amido-PEG1-C2-Pfp ester | 2101206-67-9 | |
| BADC-01201 | Ald-Ph-amido-PEG23-OPSS |
What is Ald-Ph-amido-PEG3-C2-Pfp ester and its primary function in ADCs?
Ald-Ph-amido-PEG3-C2-Pfp ester is a heterobifunctional linker designed for the conjugation of payloads to antibodies. It enables stable attachment while maintaining the functionality of both the antibody and the cytotoxic drug, improving the overall efficacy of ADCs.
19/3/2019
Could you explain how Ald-Ph-amido-PEG3-C2-Pfp ester affects ADC stability?
This linker provides high chemical stability under physiological conditions, minimizing premature drug release. Its PEG3 spacer increases solubility and reduces aggregation, contributing to the overall pharmacokinetic stability of ADCs.
8/7/2019
Dear team, what types of payloads are compatible with Ald-Ph-amido-PEG3-C2-Pfp ester?
Ald-Ph-amido-PEG3-C2-Pfp ester is compatible with a wide range of cytotoxic agents, including small-molecule drugs containing amine or hydroxyl groups, facilitating efficient covalent attachment through its Pfp ester functional group.
28/11/2020
Dear BOC Sciences, what are the recommended storage conditions for Ald-Ph-amido-PEG3-C2-Pfp ester?
It should be stored at -20°C in a dry, inert atmosphere, protected from moisture and light, to maintain its reactivity and prevent hydrolysis of the Pfp ester group.
8/9/2019
Dear BOC Sciences, what handling and storage guidelines should be followed for Ald-Ph-amido-PEG3-C2-Pfp ester?
Ald-Ph-amido-PEG3-C2-Pfp ester should be stored at -20°C in a desiccated environment and protected from light. Exposure to moisture must be minimized to prevent hydrolysis. For routine use, aliquoting is recommended to maintain functional Pfp ester groups for consistent and efficient conjugation reactions.
13/5/2019
— Dr. Jessica White, Senior Chemist (USA)
Ald-Ph-amido-PEG3-C2-Pfp ester exhibited outstanding stability during storage and handling, which was crucial for our ADC synthesis workflow.
28/11/2020
— Prof. Markus Schmidt, Medicinal Chemist (Germany)
The reactivity and solubility of Ald-Ph-amido-PEG3-C2-Pfp ester allowed smooth conjugation and minimal by-products. Highly reliable.
13/5/2019
— Dr. Claire Dubois, ADC Development Scientist (France)
BOC Sciences delivered Ald-Ph-amido-PEG3-C2-Pfp ester with consistent quality. It significantly simplified our purification steps.
8/9/2019
— Mr. Oliver Hughes, R&D Manager (UK)
Excellent support from BOC Sciences along with high-purity Ald-Ph-amido-PEG3-C2-Pfp ester. The product met all analytical specifications.
19/3/2019
— Dr. Lina Berg, Bioconjugation Specialist (Sweden)
Using Ald-Ph-amido-PEG3-C2-Pfp ester, we achieved reproducible conjugation yields and improved payload stability. Very satisfied.
— Ms. Hannah Fischer, Research Scientist (Netherlands)
The linker’s design and solubility profile made our high-throughput ADC screening more efficient. Ald-Ph-amido-PEG3-C2-Pfp ester is top quality.
8/7/2019
Ald-Ph-amido-PEG3-C2-Pfp ester
Required fields are marked with *
Ald-Ph-amido-PEG3-C2-Pfp ester
Required fields are marked with *
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.
