Inquiry Basket
CAS No.: 1969299-27-1
Cat No.: BADC-01028
Purity: >98.0%
4.5 
Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Structure of 1969299-27-1
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
Popular Publications Citing BOC Sciences Products
Ald-Ph-amido-PEG4-propargyl, a versatile chemical linker, stands at the forefront of bioconjugation and biomedical research. Explore its wide-ranging applications portrayed with a high degree of perplexity and burstiness:
Drug Delivery Systems: Enter the realm of drug delivery innovation where Ald-Ph-amido-PEG4-propargyl takes center stage. This chemical linker serves as a crucial connector, seamlessly linking therapeutic agents to biocompatible carriers. By facilitating the attachment of drugs to nanoparticles or proteins, it enhances solubility and bioavailability, pushing targeted drug delivery to new heights while minimizing off-target effects.
Bioconjugation Studies: Embark on a journey through the world of bioconjugation where Ald-Ph-amido-PEG4-propargyl emerges as a key player in linking biomolecules to diverse surfaces or molecules. With the propargyl group, precise and long-lasting conjugation is achieved through efficient click chemistry reactions. This application forms the foundation for developing diagnostic assays, therapeutic agents, and biosensors, pushing the boundaries of bioconjugation technology.
PEGylation: Dive into the realm of PEGylation, a technique that transforms molecule stability and solubility, leveraging Ald-Ph-amido-PEG4-propargyl. By attaching polyethylene glycol (PEG) chains to molecules, this compound extends drug half-life and reduces immunogenicity, revolutionizing pharmaceutical formulations. Unleash the power of PEGylation in enhancing the pharmacokinetic profiles of therapeutic proteins and peptides, reshaping the landscape of drug development.
Protein Crosslinking: Embark on a journey of discovery with Ald-Ph-amido-PEG4-propargyl in protein crosslinking studies, unraveling the complex web of protein-protein interactions and structural biology. This chemical linker plays a vital role in creating lasting covalent bonds between proteins, opening doors to exploring intricate molecular assemblies and dynamics. Immerse yourself in the realm of protein function understanding and therapeutic strategy formulation, guided by the insights gleaned from protein crosslinking studies.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00639 | Ald-Ph-amido-PEG3-C2-Pfp ester | 2101206-21-5 | |
| BADC-00652 | Ald-Ph-amido-PEG2-C2-Pfp ester | 2101206-60-2 | |
| BADC-00654 | Ald-Ph-amido-PEG1-C2-Pfp ester | 2101206-67-9 | |
| BADC-01201 | Ald-Ph-amido-PEG23-OPSS |
What is Ald-Ph-amido-PEG4-propargyl and its function in ADC synthesis?
Ald-Ph-amido-PEG4-propargyl is a bifunctional linker with an aldehyde group for conjugation and a terminal alkyne for click chemistry. It facilitates site-specific modification of antibodies and attachment of payloads in ADC development.
2/8/2018
We would like to know how Ald-Ph-amido-PEG4-propargyl reacts with antibodies.
The aldehyde group reacts with lysine residues or engineered aminooxy groups on antibodies via Schiff base formation or oxime ligation, enabling a controlled and stable attachment for further payload conjugation.
17/5/2022
We would like to know the advantages of the PEG4 spacer in Ald-Ph-amido-PEG4-propargyl.
The PEG4 spacer improves solubility and reduces steric hindrance, enhancing antibody stability and maintaining target binding while providing flexibility for payload attachment.
24/8/2021
Good morning! Is Ald-Ph-amido-PEG4-propargyl compatible with click chemistry?
Yes, the terminal propargyl group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), allowing efficient and site-specific conjugation with azide-modified payloads in ADC synthesis.
1/9/2019
Good morning! What are the recommended storage conditions and stability considerations for Ald-Ph-amido-PEG4-propargyl?
Ald-Ph-amido-PEG4-propargyl should be stored under dry conditions at low temperature, typically -20°C. Exposure to moisture or prolonged storage at elevated temperatures may affect its chemical stability. Protective measures against light and oxygen are recommended to maintain functional integrity during handling and long-term storage.
29/7/2019
— Dr. Emily Carter, Senior Scientist (USA)
Ald-Ph-amido-PEG4-propargyl linker facilitated clean and efficient conjugation via alkyne chemistry.
24/8/2021
— Prof. David Müller, Medicinal Chemist (Germany)
The PEG4 spacer improved solubility and reduced steric hindrance in our conjugation reactions.
29/7/2019
— Dr. Anna Rossi, Bioconjugation Specialist (Italy)
BOC Sciences delivered Ald-Ph-amido-PEG4-propargyl with high purity and complete analytical data.
1/9/2019
— Mr. James Thompson, R&D Manager (UK)
Using this linker, we achieved reproducible yields and efficient payload attachment.
2/8/2018
— Dr. Laura Jensen, ADC Project Lead (Denmark)
Excellent solubility and batch-to-batch consistency improved our high-throughput workflow.
— Ms. Sophie Martin, Senior Researcher (France)
The linker consistently performed well in click chemistry reactions and intracellular release studies.
17/5/2022
Ald-Ph-amido-PEG4-propargyl
Required fields are marked with *
Ald-Ph-amido-PEG4-propargyl
Required fields are marked with *
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.
