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Doxorubicin-SMCC

  CAS No.: 400647-59-8   Cat No.: BADC-01122   Purity: >99.3% 4.5  

Doxorubicin-SMCC is a pre-activated ADC linker-payload combining a cytotoxic agent with a maleimide NHS ester linker. Enables targeted drug delivery by conjugating with antibody thiol groups.

Doxorubicin-SMCC

Structure of 400647-59-8

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Category
ADC Linker
Molecular Formula
C39H42N2O14
Molecular Weight
762.76
Shipping
Room temperature
Shipping
Store at -5°C,keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)cyclohexanecarboxamide
IUPAC Name
4-[(2,5-dioxopyrrol-1-yl)methyl]-N-[(2S,3S,4S,6R)-3-hydroxy-2-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-4-yl]cyclohexane-1-carboxamide
Canonical SMILES
CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)NC(=O)C6CCC(CC6)CN7C(=O)C=CC7=O)O
InChI
InChI=1S/C39H42N2O14/c1-17-33(46)22(40-38(51)19-8-6-18(7-9-19)15-41-26(44)10-11-27(41)45)12-28(54-17)55-24-14-39(52,25(43)16-42)13-21-30(24)37(50)32-31(35(21)48)34(47)20-4-3-5-23(53-2)29(20)36(32)49/h3-5,10-11,17-19,22,24,28,33,42,46,48,50,52H,6-9,12-16H2,1-2H3,(H,40,51)/t17-,18?,19?,22-,24-,28-,33+,39-/m0/s1
InChIKey
OTQOQHVWNBKSGU-SAJDXUNTSA-N
Solubility
10 mm in DMSO
Appearance
Solid powder
Quantity
Milligrams-Grams
Quality Standard
Enterprise standard
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at -5°C,keep in dry and avoid sunlight.
Form
Solid

Doxorubicin-SMCC, a pivotal conjugate utilized in targeted cancer therapies and biomedical research, showcases a multitude of applications. Here are four key applications of Doxorubicin-SMCC:

Targeted Cancer Therapy: Pioneering the landscape of targeted cancer therapy, Doxorubicin-SMCC assumes a pivotal role in crafting antibody-drug conjugates (ADCs) tailored to selectively target cancer cells while preserving the integrity of healthy tissues. By conjugating Doxorubicin-SMCC with antibodies recognizing tumor-specific antigens, the drug is precisely delivered to malignant cells, ushering in a paradigm shift in treatment precision and mitigating systemic toxicity, ushering in a sophisticated approach to cancer therapy.

Drug Delivery System Research: Positioned at the forefront of drug delivery system exploration, Doxorubicin-SMCC serves as a cornerstone for delving into and refining drug delivery mechanisms. Researchers delve into the intricate dynamics of stability, release kinetics, and biodistribution of this versatile conjugate across diverse formulations. Revelations derived from unraveling these complexities have the potential to drive the evolution of advanced targeted drug delivery platforms, potentially enhancing treatment outcomes across a spectrum of medical conditions.

Bioconjugation Studies: In the realm of bioconjugation research, Doxorubicin-SMCC emerges as a catalytic agent for dissecting the chemical bonds between drugs and targeting molecules. By harnessing the SMCC linker, researchers securely anchor Doxorubicin to proteins or peptides, paving the way for innovative conjugation strategies. Discoveries stemming from these intricate studies hold the promise of catalyzing the development of novel therapeutics and diagnostic tools.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: MMAF | SMCC | INNO-206 | D8-MMAD | 3-Azido-D-alanine hydrochloride | DBCO-(PEG2-VC-PAB-MMAE)2 | 3-Azidopropionic Acid Sulfo-NHS ester | 3-Azidopropanol | Duostatin 5 | MC-VC-PABC-SP 141 | Doxorubicin-SMCC
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