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CAS No.: 400647-59-8
Cat No.: BADC-01122
Purity: >99.3%
4.5 
Doxorubicin-SMCC is a pre-activated ADC linker-payload combining a cytotoxic agent with a maleimide NHS ester linker. Enables targeted drug delivery by conjugating with antibody thiol groups.
Structure of 400647-59-8
* For research and manufacturing use only. We do not sell to patients.
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Popular Publications Citing BOC Sciences Products
Doxorubicin-SMCC, a pivotal conjugate utilized in targeted cancer therapies and biomedical research, showcases a multitude of applications. Here are four key applications of Doxorubicin-SMCC:
Targeted Cancer Therapy: Pioneering the landscape of targeted cancer therapy, Doxorubicin-SMCC assumes a pivotal role in crafting antibody-drug conjugates (ADCs) tailored to selectively target cancer cells while preserving the integrity of healthy tissues. By conjugating Doxorubicin-SMCC with antibodies recognizing tumor-specific antigens, the drug is precisely delivered to malignant cells, ushering in a paradigm shift in treatment precision and mitigating systemic toxicity, ushering in a sophisticated approach to cancer therapy.
Drug Delivery System Research: Positioned at the forefront of drug delivery system exploration, Doxorubicin-SMCC serves as a cornerstone for delving into and refining drug delivery mechanisms. Researchers delve into the intricate dynamics of stability, release kinetics, and biodistribution of this versatile conjugate across diverse formulations. Revelations derived from unraveling these complexities have the potential to drive the evolution of advanced targeted drug delivery platforms, potentially enhancing treatment outcomes across a spectrum of medical conditions.
Bioconjugation Studies: In the realm of bioconjugation research, Doxorubicin-SMCC emerges as a catalytic agent for dissecting the chemical bonds between drugs and targeting molecules. By harnessing the SMCC linker, researchers securely anchor Doxorubicin to proteins or peptides, paving the way for innovative conjugation strategies. Discoveries stemming from these intricate studies hold the promise of catalyzing the development of novel therapeutics and diagnostic tools.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00892 | N-(Iodoacetamido)-Doxorubicin | 114390-30-6 | |
| 1547491-85-9 | N-([1,1'-biphenyl]-4-yl)-[1,1':3',1''-terphenyl]-4'-amine | 1547491-85-9 | |
| BADC-00042 | Daunorubicin | 20830-81-3 | |
| BADC-00039 | Doxorubicin | 23214-92-8 | |
| BADC-00038 | Doxorubicin hydrochloride | 25316-40-9 | |
| BADC-00363 | Aldoxorubicin hydrochloride | 480998-12-7 | |
| BADC-01412 | MA-PEG4-VC-PAB-DMAE-Doxorubicin | ||
| BADC-01462 | N3-PEG4-DYKDDDD-Doxorubicin | ||
| BADC-01463 | Azide-PEG4-VC-PAB-Doxorubicin | ||
| BADC-01464 | N3-PEG4-YPYDVPDYA-Doxorubicin |
What is Doxorubicin-SMCC?
Doxorubicin-SMCC is an ADC linker-payload conjugate combining doxorubicin with the SMCC linker. It is designed for controlled intracellular release following antibody-mediated endocytosis, enabling selective cytotoxicity while maintaining conjugate stability in circulation for research and development purposes.
29/8/2020
Could you advise on the recommended storage conditions for Doxorubicin-SMCC?
Doxorubicin-SMCC should be stored at low temperatures under inert atmosphere, protected from light and moisture. Proper storage maintains chemical integrity, prevents premature degradation, and ensures reproducibility of ADC experiments and preclinical evaluations.
12/8/2021
We would like to know what specifications are available for Doxorubicin-SMCC.
Doxorubicin-SMCC is provided with detailed specifications including molecular weight, linker chemistry, and solubility characteristics. These parameters support ADC design, formulation, and experimental reproducibility without disclosing purity values.
10/10/2022
Dear team, are there support documents available for Doxorubicin-SMCC?
Yes, Doxorubicin-SMCC is supplied with comprehensive technical documentation, including chemical structure, handling instructions, and suggested conjugation protocols. These documents aid researchers in optimizing ADC construction and experimental workflows.
19/7/2020
Good morning! How is the quality of Doxorubicin-SMCC typically tested?
Quality of Doxorubicin-SMCC is verified through analytical techniques such as NMR, LC-MS, and HPLC for structural confirmation and stability assessment. This ensures the linker-payload is suitable for ADC research applications.
7/7/2019
— Dr. James Carter, Senior Scientist (USA)
We tested Doxorubicin-SMCC in our ADC development project and were impressed by its exceptional purity and consistency. It streamlined our conjugation workflow significantly.
10/10/2022
— Prof. Anna Müller, Biochemistry Researcher (Germany)
BOC Sciences delivered Doxorubicin-SMCC ahead of schedule, which allowed us to accelerate our preclinical testing. Highly recommended for reliable ADC research.
7/7/2019
— Dr. Michael Thompson, ADC Development Scientist (UK)
The lot-to-lot consistency of Doxorubicin-SMCC exceeded our expectations. It facilitated reproducible results in our cytotoxicity assays.
19/7/2020
— Ms. Emily Johnson, Research Associate (Canada)
Using Doxorubicin-SMCC, we achieved high conjugation efficiency without additional optimization. This product truly enhanced our workflow.
29/8/2020
— Dr. Laurent Dupont, Medicinal Chemist (France)
Doxorubicin-SMCC from BOC Sciences provided excellent solubility and stability, critical for our long-term ADC stability studies.
— Dr. Rachel Smith, Bioconjugation Specialist (USA)
The technical support team provided clear guidance for handling Doxorubicin-SMCC. Their advice helped us achieve optimal yields in ADC synthesis.
12/8/2021
Doxorubicin-SMCC
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Doxorubicin-SMCC
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