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Maleimide-NH-PEG4-CH2CH2COOPFP Ester is a versatile compound used in the biomedical industry for the preparation of bioconjugates. It serves as a reactive linker, enabling the conjugation of drugs or biomolecules to specific targets. Particularly, it is commonly utilized in targeted drug delivery systems for the treatment of various diseases, such as cancer and autoimmune disorders.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00444 | -- | $-- | Inquiry |
Maleimide-NH-PEG4-CH2CH2COOPFP Ester is a highly reactive and versatile compound commonly used in bioconjugation for targeted drug delivery and protein labeling. The maleimide group reacts efficiently with thiol groups on biomolecules such as proteins, peptides, or antibodies, allowing for the formation of stable covalent bonds. The PEG4 (polyethylene glycol) spacer provides flexibility and water solubility, enhancing the stability and biocompatibility of the conjugate. The OPFP ester group, which is a reactive electrophilic moiety, facilitates the conjugation of the compound to a wide range of molecules. This reactivity makes Maleimide-NH-PEG4-CH2CH2COOPFP Ester an ideal tool for creating conjugates for drug delivery, diagnostic imaging, and therapeutic applications.
One of the key applications of Maleimide-NH-PEG4-CH2CH2COOPFP Ester is in the development of targeted antibody-drug conjugates (ADCs) for cancer therapy. By attaching cytotoxic drugs to antibodies or peptides through the maleimide linkage, the compound enables the selective delivery of toxic agents to tumor cells. The PEG4 spacer enhances the solubility and circulation half-life of the conjugate, ensuring that the drug reaches the tumor site before being released. The OPFP ester group allows for efficient and controlled conjugation, which can be cleaved or modified as required. This approach helps to minimize off-target toxicity and maximizes the therapeutic effect by delivering the drug directly to the cancer cells. This strategy is particularly useful in treating tumors that overexpress specific cell surface markers.
Another important application of Maleimide-NH-PEG4-CH2CH2COOPFP Ester is in the creation of diagnostic probes for imaging and detection. The maleimide group allows the conjugation of this compound to biomolecules such as peptides or antibodies that target specific tumor-associated antigens. Once conjugated, the compound can be used in imaging techniques such as positron emission tomography (PET) or fluorescence imaging, enabling the precise visualization of tumors in real-time. The PEG4 spacer ensures the conjugate has good solubility and stability in biological environments, which is crucial for in vivo imaging. This application is beneficial for the early detection of cancers, monitoring treatment responses, and assessing tumor localization during surgery.
Maleimide-NH-PEG4-CH2CH2COOPFP Ester is also utilized in the development of peptide-based delivery systems. By attaching therapeutic peptides or nucleic acids to the compound, it is possible to create conjugates with enhanced targeting ability and improved pharmacokinetics. The maleimide group allows for the selective conjugation to cysteine or other thiol-functionalized peptides, while the PEG4 spacer increases the solubility and reduces immunogenicity. This conjugate can be used in gene therapy, protein therapy, or RNA delivery, where targeted delivery to specific tissues or cells is essential for maximizing therapeutic outcomes. The OPFP ester moiety can be used to further modify the conjugates for controlled release or activation, making it a useful tool in drug delivery and gene therapy applications.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
