Boc-(4R)-4-azido-D-proline is a protected amino acid linker with an azido group for bioorthogonal conjugation. Useful in ADC synthesis, especially for site-specific, stereochemically defined payload attachment.
Structure of 650601-59-5
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Capabilities & Facilities
Boc-(4R)-4-azido-D-proline is a versatile compound used in various chemical and biological research applications. Here are some key applications of Boc-(4R)-4-azido-D-proline:
Peptide Synthesis: Boc-(4R)-4-azido-D-proline is used as a building block in the synthesis of peptides. Its azido group allows for the introduction of additional functional groups via click chemistry, facilitating the modification of peptides post-synthesis. This aids in creating complex peptide constructs for use in drug development and biochemical studies.
Chemical Biology: This compound serves as an important tool in chemical biology for studying protein structures and interactions. The azido group can be selectively reacted with alkynes through copper-catalyzed azide-alkyne cycloaddition (CuAAC), allowing researchers to label proteins with probes. This is invaluable for imaging and tracking proteins within cells.
Protein Engineering: In protein engineering, Boc-(4R)-4-azido-D-proline is incorporated into proteins to introduce site-specific modifications. The azide moiety can be used for bioconjugation with other molecules, such as dyes and therapeutic agents. This approach is crucial for developing novel protein-based therapeutics and diagnostics.
Bioorthogonal Chemistry: Boc-(4R)-4-azido-D-proline is utilized in bioorthogonal reactions, which occur without interfering with native biochemical processes. Its use in bioorthogonal chemistry enables precise modifications in living cells, facilitating studies on cellular functions and dynamics. This technique is particularly useful for in vivo studies and therapeutic interventions.
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