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| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00495 | -- | $-- | Inquiry |
Fmoc-Phe-Lys(Trt)-PAB-PNP is a multifunctional compound used in peptide synthesis, bioconjugation, and drug delivery systems. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the N-terminal amino group, enabling precise sequential peptide assembly through solid-phase peptide synthesis (SPPS). This protection facilitates the incorporation of the compound into complex peptide chains with high specificity and efficiency, making it a valuable building block in advanced biochemical applications.
The Fmoc-Phe-Lys(Trt) core combines phenylalanine (Phe) and lysine (Lys) residues, with the Trt (trityl) group protecting the side chain amino group of lysine. This dual protection scheme ensures stability during synthesis and allows for selective functionalization of the lysine residue. This functionality is particularly useful in designing peptide-drug conjugates (PDCs) and targeted delivery systems, where the lysine side chain serves as a critical attachment point for therapeutic agents, imaging probes, or other bioactive molecules.
The PAB (para-aminobenzyl) moiety is a key feature of Fmoc-Phe-Lys(Trt)-PAB-PNP, acting as a self-immolative linker. This property enables controlled release of payloads upon cleavage of the peptide or linker sequence. In drug delivery, the PAB linker ensures efficient release of attached drugs or toxins in response to specific triggers, such as enzymatic activity or changes in pH. This mechanism is essential for the design of antibody-drug conjugates (ADCs) and other targeted therapies, enabling precise release of cytotoxic agents at diseased sites while minimizing systemic toxicity.
The PNP (p-nitrophenyl) group further enhances the versatility of Fmoc-Phe-Lys(Trt)-PAB-PNP by serving as a leaving group in nucleophilic substitution reactions. This feature allows for the conjugation of a wide range of functional groups, making the compound a valuable tool in bioconjugation and surface modification. Applications include the attachment of peptides to nanoparticles, polymers, or other biomaterials for use in drug delivery, diagnostics, and biomaterial engineering.
Fmoc-Phe-Lys(Trt)-PAB-PNP is also employed in the development of protease-sensitive linkers. By incorporating enzyme-cleavable sequences, the compound enables precise drug release in response to proteolytic activity in disease-specific environments, such as tumors. This property is crucial for the development of advanced therapeutic strategies, including prodrugs and stimuli-responsive drug delivery systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
