Fmoc-Phe-Lys(Trt)-PAB - CAS 1116085-98-3

Fmoc-Phe-Lys(Trt)-PAB - CAS 1116085-98-3 Catalog number: BADC-00709

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Fmoc-Phe-Lys(Trt)-PAB is a linker for antibody-drug-conjugation (ADC).

Category
ADCs Linker
Product Name
Fmoc-Phe-Lys(Trt)-PAB
CAS
1116085-98-3
Catalog Number
BADC-00709
Molecular Formula
C56H54N4O5
Molecular Weight
863.00
Purity
95%
Fmoc-Phe-Lys(Trt)-PAB

Ordering Information

Catalog Number Size Price Quantity
BADC-00709 -- $-- Inquiry
Description
Fmoc-Phe-Lys(Trt)-PAB is a linker for antibody-drug-conjugation (ADC).
Synonyms
(9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-amino-1-oxo-6-(tritylamino)hexan-2-yl)(4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)N(C2=CC=C(C=C2)COC(=O)OC3=CC=C(C=C3)[N+](=O)[O-])C(CCCCNC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C(=O)N)NC(=O)OCC7C8=CC=CC=C8C9=CC=CC=C79
InChI
InChI=1S/C63H57N5O9/c64-59(69)58(31-17-18-40-65-63(46-21-7-2-8-22-46,47-23-9-3-10-24-47)48-25-11-4-12-26-48)67(49-34-32-45(33-35-49)42-76-62(72)77-51-38-36-50(37-39-51)68(73)74)60(70)57(41-44-19-5-1-6-20-44)66-61(71)75-43-56-54-29-15-13-27-52(54)53-28-14-16-30-55(53)56/h1-16,19-30,32-39,56-58,65H,17-18,31,40-43H2,(H2,64,69)(H,66,71)/t57-,58-/m0/s1
InChIKey
LOGURWMJSNXIEZ-YQOHNZFASA-N
Shipping
Room temperature, or blue ice upon request.
Storage
-20°C

Fmoc-Phe-Lys(Trt)-PAB, a versatile peptide building block, plays a pivotal role in solid-phase peptide synthesis (SPPS) for constructing intricate peptide chains. Here are four key applications of Fmoc-Phe-Lys(Trt)-PAB:

Peptide Drug Development: Widely used in synthesizing peptide-based drugs, Fmoc-Phe-Lys(Trt)-PAB is crucial in combating various medical conditions like diabetes, cancer, and infectious diseases. The Fmoc protecting group facilitates selective reactions during SPPS, enabling the precise assembly of therapeutic peptides. This precision is paramount in developing potent and stable peptide drugs with targeted efficacy.

Enzyme Substrate Screening: In the realm of peptide library creation, Fmoc-Phe-Lys(Trt)-PAB aids in screening potential enzyme substrates, allowing researchers to construct diverse peptide sequences for testing against different enzymes. These experiments are instrumental in uncovering specific substrate-enzyme interactions, offering insights into enzyme specificity and kinetics through a multifaceted approach.

Biomaterial Research: Within biomaterial design, Fmoc-Phe-Lys(Trt)-PAB can be integrated into peptide sequences that autonomously assemble into nanostructures or hydrogels, finding applications in tissue engineering, drug delivery, and regenerative medicine. The meticulous control over peptide structure afforded by SPPS techniques enhances the functional attributes of resultant biomaterials, fostering innovation in the field.

Structural Biology: Employed in synthesizing peptides for structural biology investigations, including nuclear magnetic resonance (NMR) and X-ray crystallography studies, Fmoc-Phe-Lys(Trt)-PAB enables accurate peptide synthesis to generate protein fragments or peptide inhibitors for three-dimensional structure elucidation. This knowledge is indispensable for unraveling protein functionality and facilitating drug design through a comprehensive exploration of molecular intricacies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: mPEG8-amine | Fmoc-Phe-Lys(Trt)-PAB
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