Name: Fmoc-Phe-Lys(Trt)-PAB
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Synonyms

(9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-amino-1-oxo-6-(tritylamino)hexan-2-yl)(4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Canonical SMILES

C1=CC=C(C=C1)CC(C(=O)N(C2=CC=C(C=C2)COC(=O)OC3=CC=C(C=C3)[N+](=O)[O-])C(CCCCNC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C(=O)N)NC(=O)OCC7C8=CC=CC=C8C9=CC=CC=C79

InChI

InChI=1S/C63H57N5O9/c64-59(69)58(31-17-18-40-65-63(46-21-7-2-8-22-46,47-23-9-3-10-24-47)48-25-11-4-12-26-48)67(49-34-32-45(33-35-49)42-76-62(72)77-51-38-36-50(37-39-51)68(73)74)60(70)57(41-44-19-5-1-6-20-44)66-61(71)75-43-56-54-29-15-13-27-52(54)53-28-14-16-30-55(53)56/h1-16,19-30,32-39,56-58,65H,17-18,31,40-43H2,(H2,64,69)(H,66,71)/t57-,58-/m0/s1

InChIKey

LOGURWMJSNXIEZ-YQOHNZFASA-N

Shipping

Room temperature, or blue ice upon request.

Storage

-20°C

Fmoc-Phe-Lys(Trt)-PAB, a versatile peptide building block, plays a pivotal role in solid-phase peptide synthesis (SPPS) for constructing intricate peptide chains. Here are four key applications of Fmoc-Phe-Lys(Trt)-PAB:

Peptide Drug Development: Widely used in synthesizing peptide-based drugs, Fmoc-Phe-Lys(Trt)-PAB is crucial in combating various medical conditions like diabetes, cancer, and infectious diseases. The Fmoc protecting group facilitates selective reactions during SPPS, enabling the precise assembly of therapeutic peptides. This precision is paramount in developing potent and stable peptide drugs with targeted efficacy.

Enzyme Substrate Screening: In the realm of peptide library creation, Fmoc-Phe-Lys(Trt)-PAB aids in screening potential enzyme substrates, allowing researchers to construct diverse peptide sequences for testing against different enzymes. These experiments are instrumental in uncovering specific substrate-enzyme interactions, offering insights into enzyme specificity and kinetics through a multifaceted approach.

Biomaterial Research: Within biomaterial design, Fmoc-Phe-Lys(Trt)-PAB can be integrated into peptide sequences that autonomously assemble into nanostructures or hydrogels, finding applications in tissue engineering, drug delivery, and regenerative medicine. The meticulous control over peptide structure afforded by SPPS techniques enhances the functional attributes of resultant biomaterials, fostering innovation in the field.

Structural Biology: Employed in synthesizing peptides for structural biology investigations, including nuclear magnetic resonance (NMR) and X-ray crystallography studies, Fmoc-Phe-Lys(Trt)-PAB enables accurate peptide synthesis to generate protein fragments or peptide inhibitors for three-dimensional structure elucidation. This knowledge is indispensable for unraveling protein functionality and facilitating drug design through a comprehensive exploration of molecular intricacies.