Fmoc-Phe-Lys(Boc)-PAB-PNP - CAS 1646299-50-4

Fmoc-Phe-Lys(Boc)-PAB-PNP - CAS 1646299-50-4 Catalog number: BADC-00980

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Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

General Information

Category
ADCs Linker
Product Name
Fmoc-Phe-Lys(Boc)-PAB-PNP
CAS
1646299-50-4
Catalog Number
BADC-00980
Molecular Formula
C49H51N5O11
Molecular Weight
885.96 g/mol
Purity
>98.6%
Appearance
Solid Powder
Synonyms
[4-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoyl]amino]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
Solubility
DMSO : 6 mg/mL (ultrasonic);H2O : < 0.1 mg/mL
Storage
Store at -5°C,keep in dry and avoid sunlight.
Shelf Life
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
Shipping
Room temperature, or blue ice upon request.
Canonical SMILES
CC(C)(C)OC(=O)NCCCCC(C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)C(CC3=CC=CC=C3)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46
InChI Key
AHKVECQGASADRU-MJPWBCPGSA-N
InChI
InChI=1S/C49H51N5O11/c1-49(2,3)65-46(57)50-28-12-11-19-42(44(55)51-34-22-20-33(21-23-34)30-63-48(59)64-36-26-24-35(25-27-36)54(60)61)52-45(56)43(29-32-13-5-4-6-14-32)53-47(58)62-31-41-39-17-9-7-15-37(39)38-16-8-10-18-40(38)41/h4-10,13-18,20-27,41-43H,11-12,19,28-31H2,1-3H3,(H,50,57)(H,51,55)(H,52,56)(H,53,58)/t42-,43-/m0/s1
BiologicalActivity
Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). IC50 & Target:

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Historical Records: N-Boc-PEG5-bromide | NH2-PEG9-acid | N-(2-(2,3-Dimethylphenoxy)ethyl)-4-Formylbenzamide | N-Butanoyl-L-homoserine lactone | Hydroxy-PEG3-SS-PEG3-alcohol | SPDPH | N-(2-(4-Fluorophenoxy)ethyl)-4-Formylbenzamide | Muscarinic toxin 2 | Fmoc-Phe-Lys(Boc)-PAB-PNP
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