6-O-2-Propyn-1-yl-D-galactose - CAS 881895-59-6

6-O-2-Propyn-1-yl-D-galactose - CAS 881895-59-6 Catalog number: BADC-00703

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6-O-2-Propyn-1-yl-D-galactose is a nonclaevable glycolinker for the functionalization of cytotoxic drugs and applications in antibody-drug conjugation.

Category
ADCs Linker
Product Name
6-O-2-Propyn-1-yl-D-galactose
CAS
881895-59-6
Catalog Number
BADC-00703
Molecular Formula
C9H14O6
Molecular Weight
218.2
6-O-2-Propyn-1-yl-D-galactose

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BADC-00703 -- $--
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Description
6-O-2-Propyn-1-yl-D-galactose is a nonclaevable glycolinker for the functionalization of cytotoxic drugs and applications in antibody-drug conjugation.
Synonyms
6-O-2-Propyn-1-yl-D-galactose
IUPAC Name
2,3,4,5-tetrahydroxy-6-prop-2-ynoxyhexanal
Canonical SMILES
O=C[C@@H]([C@H]([C@H]([C@@H](COCC#C)O)O)O)O
InChI
InChI=1S/C9H14O6/c1-2-3-15-5-7(12)9(14)8(13)6(11)4-10/h1,4,6-9,11-14H,3,5H2
InChIKey
ITQZDWPQQZDNAZ-UHFFFAOYSA-N
Shipping
Room temperature, or blue ice upon request.
1.Introducing Glycolinkers for the Functionalization of Cytotoxic Drugs and Applications in Antibody-Drug Conjugation Chemistry
Ekholm FS, Pynnönen H, Vilkman A, Pitkänen V, Helin J, Saarinen J, Satomaa T
Antibody-drug conjugates (ADCs) are promising alternatives to naked antibodies for selective drug-delivery applications and treatment of diseases such as cancer. Construction of ADCs relies upon site-selective, efficient and mild conjugation technologies. The choice of a chemical linker is especially important, as it affects the overall properties of the ADC. We envisioned that hydrophilic bifunctional chemical linkers based on carbohydrates would be a useful class of derivatization agents for the construction of linker-drug conjugates and ADCs. Herein we describe the synthesis of carbohydrate-based derivatization agents, glycolinker-drug conjugates featuring the tubulin inhibitor monomethyl auristatin E and an ADC based on an anti-EGFR antibody. In addition, an initial in vitro cytotoxicity evaluation of the individual components and the ADC is provided against EGFR-positive cancer cells.
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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