Name: MAC glucuronide linker-1
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Synonyms

methyl (2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[2-[[2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetyl]amino]-4-(2-methylsulfonylethylcarbamoyloxymethyl)phenoxy]oxane-2-carboxylate

IUPAC Name

methyl (2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[2-[[2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]acetyl]amino]-4-(2-methylsulfonylethylcarbamoyloxymethyl)phenoxy]oxane-2-carboxylate

Canonical SMILES

CC(=O)OC1C(C(OC(C1OC(=O)C)OC2=C(C=C(C=C2)COC(=O)NCCS(=O)(=O)C)NC(=O)CN(C)C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)C(=O)OC)OC(=O)C

InChI

InChI=1S/C42H47N3O17S/c1-23(46)58-35-36(59-24(2)47)38(60-25(3)48)40(62-37(35)39(50)55-5)61-33-16-15-26(21-56-41(51)43-17-18-63(6,53)54)19-32(33)44-34(49)20-45(4)42(52)57-22-31-29-13-9-7-11-27(29)28-12-8-10-14-30(28)31/h7-16,19,31,35-38,40H,17-18,20-22H2,1-6H3,(H,43,51)(H,44,49)/t35-,36-,37-,38+,40+/m0/s1

InChIKey

HKCMXFVQNGHVML-KWMSUFDQSA-N

Solubility

10 mm in DMSO

Appearance

Solid

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature

Storage

Store at -5°C,keep in dry and avoid sunlight.

Form

Solid

Biological Activity

MAC glucuronide linker-1 is a nonclaevable ADC linker for antibody-drug-conjugations (ADCs)[1]

MAC glucuronide linker-1 is a specialized chemical compound commonly utilized in the development of antibody-drug conjugates (ADCs). This linker is known for its stability and ability to facilitate the controlled release of the cytotoxic drug payload at the target site. In ADC formulations, MAC glucuronide linker-1 plays a critical role by connecting the antibody to the drug while maintaining the integrity of the conjugate during circulation. Once the ADC reaches the targeted cancer cells, the linker is cleaved by specific enzymes, such as glucuronidase, enabling the release of the cytotoxic agent in the tumor microenvironment. This controlled release is essential for reducing off-target toxicity and improving therapeutic efficacy.

Another significant application of MAC glucuronide linker-1 is in the development of targeted therapies for diseases beyond cancer, including viral infections. Due to its stable yet cleavable nature, it is being explored for the delivery of antiviral agents. The glucuronide linkage provides a means to selectively activate the therapeutic agent at the site of infection, ensuring that the drug is released only in the vicinity of the virus. This enhances the precision of treatment, minimizing systemic side effects and optimizing therapeutic outcomes.

In addition to its use in ADCs and antiviral therapies, MAC glucuronide linker-1 is also being studied for its potential in drug delivery systems that target specific tissues or organs. Its ability to link therapeutic compounds to carrier molecules, such as nanoparticles, enables more effective delivery to specific sites in the body. This has promising implications in the treatment of diseases like rheumatoid arthritis or cardiovascular conditions, where localized delivery of drugs could dramatically improve efficacy and reduce the risk of side effects associated with systemic drug administration.