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CAS No.: 2222981-71-5
Cat No.: BADC-01085
Purity: ≥95.0%
4.5 
MAC glucuronide linker-1 is an enzyme-cleavable ADC linker designed for selective drug release in tumor microenvironments, enhancing targeted delivery and therapeutic efficacy in antibody-drug conjugates.
Structure of 2222981-71-5
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Popular Publications Citing BOC Sciences Products
MAC glucuronide linker-1 is a specialized chemical compound commonly utilized in the development of antibody-drug conjugates (ADCs). This linker is known for its stability and ability to facilitate the controlled release of the cytotoxic drug payload at the target site. In ADC formulations, MAC glucuronide linker-1 plays a critical role by connecting the antibody to the drug while maintaining the integrity of the conjugate during circulation. Once the ADC reaches the targeted cancer cells, the linker is cleaved by specific enzymes, such as glucuronidase, enabling the release of the cytotoxic agent in the tumor microenvironment. This controlled release is essential for reducing off-target toxicity and improving therapeutic efficacy.
Another significant application of MAC glucuronide linker-1 is in the development of targeted therapies for diseases beyond cancer, including viral infections. Due to its stable yet cleavable nature, it is being explored for the delivery of antiviral agents. The glucuronide linkage provides a means to selectively activate the therapeutic agent at the site of infection, ensuring that the drug is released only in the vicinity of the virus. This enhances the precision of treatment, minimizing systemic side effects and optimizing therapeutic outcomes.
In addition to its use in ADCs and antiviral therapies, MAC glucuronide linker-1 is also being studied for its potential in drug delivery systems that target specific tissues or organs. Its ability to link therapeutic compounds to carrier molecules, such as nanoparticles, enables more effective delivery to specific sites in the body. This has promising implications in the treatment of diseases like rheumatoid arthritis or cardiovascular conditions, where localized delivery of drugs could dramatically improve efficacy and reduce the risk of side effects associated with systemic drug administration.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00672 | MAC glucuronide linker | 2260960-07-2 | |
| BADC-01095 | MAC glucuronide linker-2 | 229977-57-5 |
What is the purpose of MAC glucuronide linker-1 in ADCs?
MAC glucuronide linker-1 is an enzymatically cleavable linker that releases payloads upon exposure to β-glucuronidase. This design allows controlled intracellular drug release in targeted cells while maintaining antibody stability during circulation.
12/3/2019
Dear team, how should MAC glucuronide linker-1 be stored?
MAC glucuronide linker-1 should be stored at -20°C under inert atmosphere and protected from moisture. Proper storage preserves the glucuronide moiety and ensures predictable enzymatic cleavage in ADC applications.
10/11/2022
Could you kindly advise which conjugation strategies are compatible with MAC glucuronide linker-1?
It can be conjugated to antibodies via amine-reactive or thiol-reactive chemistry. The linker is compatible with various payloads, allowing modular ADC synthesis and controlled drug release in the presence of β-glucuronidase.
5/11/2018
Dear team, is MAC glucuronide linker-1 suitable for in vivo ADC studies?
Yes, MAC glucuronide linker-1 has been applied in preclinical ADC research. Its enzymatic cleavability ensures targeted payload release in tumor cells with β-glucuronidase activity, reducing systemic toxicity while maintaining antibody integrity.
21/8/2021
Dear team, which supporting documentation is provided with MAC glucuronide linker-1?
MAC glucuronide linker-1 is supplied with a certificate of analysis (CoA) that includes identity confirmation, structural characterization, and recommended handling instructions. Analytical data such as NMR, MS, and HPLC are typically provided to verify linker integrity and ensure suitability for antibody-drug conjugation applications.
1/2/2017
— Dr. Emily Carter, Senior Scientist (USA)
We required a specialized linker for our ADC program, and MAC glucuronide linker-1 met all specifications. The purity and consistency were excellent, which significantly improved our conjugation efficiency.
5/11/2018
— Prof. David Müller, Medicinal Chemist (Germany)
The custom synthesis of MAC glucuronide linker-1 was delivered on time, and its stability under storage conditions exceeded our expectations. Highly recommended.
1/2/2017
— Dr. Anna Rossi, Bioconjugation Specialist (Italy)
Excellent batch-to-batch consistency of MAC glucuronide linker-1 allowed us to scale our ADC development without delays. Quality is outstanding.
21/8/2021
— Mr. James Thompson, R&D Manager (UK)
BOC Sciences’ MAC glucuronide linker-1 offered superior solubility and reactivity, which improved our ADC yield significantly. Communication throughout the process was seamless.
12/3/2019
— Dr. Laura Jensen, ADC Project Lead (Denmark)
Using MAC glucuronide linker-1, we observed minimal side reactions during conjugation. The product was exactly as described and reproducible across multiple experiments.
— Ms. Sophie Martin, Senior Researcher (France)
The linker quality and delivery timeline for MAC glucuronide linker-1 were exceptional. It greatly facilitated our high-throughput ADC screening.
10/11/2022
MAC glucuronide linker-1
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MAC glucuronide linker-1
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