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MAC glucuronide linker-1 is a nonclaevable ADC linker for antibody-drug-conjugations (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01085 | -- | $-- | Inquiry |
MAC glucuronide linker-1 is a specialized chemical compound commonly utilized in the development of antibody-drug conjugates (ADCs). This linker is known for its stability and ability to facilitate the controlled release of the cytotoxic drug payload at the target site. In ADC formulations, MAC glucuronide linker-1 plays a critical role by connecting the antibody to the drug while maintaining the integrity of the conjugate during circulation. Once the ADC reaches the targeted cancer cells, the linker is cleaved by specific enzymes, such as glucuronidase, enabling the release of the cytotoxic agent in the tumor microenvironment. This controlled release is essential for reducing off-target toxicity and improving therapeutic efficacy.
Another significant application of MAC glucuronide linker-1 is in the development of targeted therapies for diseases beyond cancer, including viral infections. Due to its stable yet cleavable nature, it is being explored for the delivery of antiviral agents. The glucuronide linkage provides a means to selectively activate the therapeutic agent at the site of infection, ensuring that the drug is released only in the vicinity of the virus. This enhances the precision of treatment, minimizing systemic side effects and optimizing therapeutic outcomes.
In addition to its use in ADCs and antiviral therapies, MAC glucuronide linker-1 is also being studied for its potential in drug delivery systems that target specific tissues or organs. Its ability to link therapeutic compounds to carrier molecules, such as nanoparticles, enables more effective delivery to specific sites in the body. This has promising implications in the treatment of diseases like rheumatoid arthritis or cardiovascular conditions, where localized delivery of drugs could dramatically improve efficacy and reduce the risk of side effects associated with systemic drug administration.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
