Name: SC-VC-PAB-DM1
Brand: BOC Sciences
Rating: 5 (1 reviews)

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 6-[[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-[[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylcarbamoyl]oxymethyl]anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-6-oxohexanoate

Canonical SMILES

C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCC(ON6C(CCC6=O)=O)=O)=O)=O)=O)C=C5)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1

InChI

InChI=1S/C61H82ClN9O19/c1-33(2)52(67-46(72)18-11-12-19-50(76)90-71-47(73)24-25-48(71)74)55(78)66-40(16-14-26-64-57(63)80)54(77)65-39-22-20-37(21-23-39)32-86-59(82)69(7)36(5)56(79)88-45-30-49(75)70(8)41-28-38(29-42(84-9)51(41)62)27-34(3)15-13-17-44(85-10)61(83)31-43(87-58(81)68-61)35(4)53-60(45,6)89-53/h13,15,17,20-23,28-29,33,35-36,40,43-45,52-53,83H,11-12,14,16,18-19,24-27,30-32H2,1-10H3,(H,65,77)(H,66,78)(H,67,72)(H,68,81)(H3,63,64,80)/b17-13+,34-15+/t35-,36+,40+,43+,44-,45+,52+,53+,60+,61+/m1/s1

Shipping

Room temperature

1.ROR1 ANTIBODY IMMUNOCONJUGATES

LANNUTTI, Brian, et al.

Cancer is the second leading cause of human death next to coronary artery disease.Receptor tyrosine kinases (RTKs) play a key role in oncogenic transformation, growth andmetastases. RTKs regulate cell differentiation, proliferation, migration, angiogenesis, andsurvival. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an evolutionarilyconserved type I membrane protein that belongs to the ROR subfamily and has extracellulardomains that contain immunoglobulin (Ig)-like, Frizzled, and Kringle domains. ROR 1-deficientmice display a variety of phenotypic defects within the skeletal and urogenital systems, as wellas postnatal growth retardation. ROR1 is expressed during embryogenesis and by a variety ofdifferent cancers, but not by normal post-partum tissues, and can be considered an oncoembryonic surface antigen. Functional data suggest that ROR1 may function in non-canonicalWNT-signaling to promote the survival of malignant cells.

Catalog	Product Name	CAS
BADC-01450	MCC-DM1	1100692-14-5
BADC-00009	DM1-SMCC	1228105-51-8
BADC-00574	Lys-SMCC-DM1	1281816-04-3
BADC-00848	MC-DM1	1375089-56-7
BADC-00020	DM1-SMe	138148-68-2
BADC-00601	Mal-VC-PAB-DM1	1464051-44-2
BADC-00010	DM1-SPP	452072-20-7
BADC-01378	S-methyl DM1	912569-84-7
BADC-01407	SPDB-DM1
BADC-01411	MPB-VC-PAB-DM1