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Azido-PEG2-NHS ester is a non-cleavable 2-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00409 | 500 mg | $469 | Inquiry |
Azido-PEG2-NHS ester, a versatile chemical reagent, plays a pivotal role in bioconjugation and molecular biology. Here are four key applications of this compound, presented with high perplexity and burstiness：
Protein Labeling：Azido-PEG2-NHS ester serves as a foundational tool for labeling proteins with azide groups, setting the stage for subsequent bio-orthogonal click chemistry reactions. This strategic labeling approach enables researchers to precisely attach molecules like fluorescent dyes or biotin to proteins, honing in on protein function, localization, and interactions within cellular environments.
Drug Delivery Systems：In the realm of targeted drug delivery systems, Azido-PEG2-NHS ester emerges as a game-changer, offering the means to modify nanoparticles or drug carriers with azide functionalities. By integrating these azide groups, carriers can be seamlessly clicked to diverse targeting ligands such as antibodies or peptides, guiding therapeutic payloads to specific cells or tissues with precision. This refined targeting capability elevates the efficacy of drug delivery systems while mitigating potential side effects.
Surface Functionalization：Delving into surface functionalization, Azido-PEG2-NHS ester takes center stage in the modification of biomaterials and devices with azide groups. This strategic modification lays the groundwork for subsequent bio-conjugation with alkyne-functionalized molecules, paving the way for the creation of bioactive surfaces tailored for applications in biosensors, diagnostics, and tissue engineering. These customized surfaces exhibit selective interactions with biological molecules, enhancing the performance and specificity of biomedical devices.
Biomolecular Cross-linking：Unveiling the utility of Azido-PEG2-NHS ester in biomolecular cross-linking, this compound proves invaluable for studying protein-protein or protein-nucleic acid interactions. By introducing azide-reactive groups on target molecules, researchers can leverage click chemistry to forge stable and specific cross-links under gentle conditions. This sophisticated approach aids in unraveling intricate molecular interactions and mapping out complex interaction networks within cellular landscapes, shedding light on the dynamic interplay of biomolecules.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
