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2, 5-Dioxopyrrolidin-1-yl 4-methyl-4-((2-methyl-5-oxo-5-(2-(trimethylsilyl)ethoxy)pentan-2-yl)disulfanyl)pentanoate is a linker for antibody-drug-conjugation (ADC).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00580 | -- | $-- | Inquiry |
One of the primary applications of 2,5-Dioxopyrrolidin-1-Yl 4-Methyl-4-((2-Methyl-5-Oxo-5-(2-(trimethylsilyl)ethoxy)pentan-2-Yl)disulfanyl)pentanoate is in the field of bioconjugation. This compound is frequently used as a linker in the conjugation of biological molecules such as peptides, proteins, and nucleotides. The presence of the N-hydroxysuccinimide (NHS) ester group allows for high efficiency in forming stable amide bonds with primary amines found in biomolecules. This ability to form covalent attachments under mild conditions makes it invaluable in creating targeted drug delivery systems, biosensors, and diagnostic tools.
Another significant application is in the synthesis of prodrugs. In medicinal chemistry, this compound can be utilized to modify active pharmaceutical ingredients (APIs) in a way that enhances their pharmacokinetic properties, including bioavailability and solubility. The disulfide linkage in the structure serves as a strategic point of modification, often breaking down in the reducing environment of the intracellular space to release the active drug. This property makes it a vital component in the development of sophisticated prodrug systems that improve the therapeutic index of pharmaceuticals.
In materials science, 2,5-Dioxopyrrolidin-1-Yl 4-Methyl-4-((2-Methyl-5-Oxo-5-(2-(trimethylsilyl)ethoxy)pentan-2-Yl)disulfanyl)pentanoate finds application as a crosslinking agent. Its ability to form stable covalent bonds under mild conditions makes it perfect for linking polymers to form hydrogels and other polymeric networks. These materials are extensively used in drug delivery, tissue engineering, and wound healing applications. The controlled release of therapeutics and the creation of biocompatible scaffolds for tissue regeneration are just some of the critical contributions of this compound to advanced materials science.
Lastly, this compound plays a crucial role in the development of antibody-drug conjugates (ADCs). ADCs are a class of highly potent biopharmaceutical drugs designed as a targeted cancer therapy. By acting as a linker, this compound ensures that the cytotoxic drug remains attached to the antibody until it reaches the tumor cell. Upon internalization by the cancer cell, the disulfide bond is reduced, releasing the cytotoxic agent. This targeted delivery minimizes the adverse effects on healthy cells and enhances the therapeutic efficacy against cancerous cells, thereby representing a sophisticated approach to cancer treatment.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
